Department of Emergency Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.
Sci Rep. 2023 Oct 23;13(1):18065. doi: 10.1038/s41598-023-44963-1.
This study determined the occurrence of cognitive impairment and mood disorders in out-of-hospital cardiac arrest (OHCA) survivors with good neurologic outcomes. We performed a retrospective, cross-sectional, single-center study with a total of 97 patients. We evaluated cognitive dysfunction via the Montreal Cognitive Assessment and Alzheimer's disease-8 mood disorders via the Patient Health Questionnaire-9 and the Hospital Anxiety and Depression Scale. We measured quality of life with the European Quality of Life 5-Dimension 5-Levels questionnaire. Cognitive impairment and mood disorders were common among patients with good neurologic recovery. There were 23 patients who experienced cognitive impairments (23.7%) and 28 who suffered from mood disorders (28.9%). Age (adjusted OR 1.07, 95% CI 1.02-1.12), mood disorders (adjusted OR 22.80, 95% CI 4.84-107.49) and hospital length of stay (adjusted OR 1.05, 95% CI 1.02-1.09) were independent risk factors for cognitive impairment. The occurrence of cognitive impairments (adjusted OR 9.94, 95% CI 2.83-35.97) and non-cardiac causes of cardiac arrest (adjusted OR 11.51, 95% CI 3.15-42.15) were risk factors for mood disorders. Quality of life was significantly lower in the OHCA survivors with each disorder than the healthy individuals. Routine screening and intervention are needed for OHCA survivors.
本研究旨在确定院外心脏骤停(OHCA)后神经功能恢复良好的幸存者中认知障碍和情绪障碍的发生情况。我们进行了一项回顾性、横断面、单中心研究,共纳入 97 例患者。我们使用蒙特利尔认知评估评估认知功能障碍,使用患者健康问卷-9 和医院焦虑抑郁量表评估阿尔茨海默病-8 情绪障碍。我们使用欧洲生活质量 5 维 5 级问卷评估生活质量。认知障碍和情绪障碍在神经功能恢复良好的患者中较为常见。有 23 例患者出现认知障碍(23.7%),28 例患者患有情绪障碍(28.9%)。年龄(调整后的 OR 1.07,95%CI 1.02-1.12)、情绪障碍(调整后的 OR 22.80,95%CI 4.84-107.49)和住院时间(调整后的 OR 1.05,95%CI 1.02-1.09)是认知障碍的独立危险因素。认知障碍的发生(调整后的 OR 9.94,95%CI 2.83-35.97)和非心源性心脏骤停(调整后的 OR 11.51,95%CI 3.15-42.15)是情绪障碍的危险因素。与健康个体相比,患有这些疾病的 OHCA 幸存者的生活质量明显更低。需要对 OHCA 幸存者进行常规筛查和干预。