Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA, USA.
Department of Internal Medicine, Division of Cardiology, Virginia Commonwealth University, Richmond, VA, USA.
Strahlenther Onkol. 2024 Jan;200(1):83-96. doi: 10.1007/s00066-023-02159-6. Epub 2023 Oct 23.
In stereotactic arrhythmia radioablation (STAR), the target is defined using multiple imaging studies and a multidisciplinary team consisting of electrophysiologist, cardiologist, cardiac radiologist, and radiation oncologist collaborate to identify the target and delineate it on the imaging studies of interest. This report describes the workflow employed in our radiotherapy department to transfer the target identified based on electrophysiology and cardiology imaging to the treatment planning image set.
The radiotherapy team was presented with an initial target in cardiac axes orientation, contoured on a wideband late gadolinium-enhanced (WB-LGE) cardiac magnetic resonance (CMR) study, which was subsequently transferred to the computed tomography (CT) scan used for treatment planning-i.e., the average intensity projection (AIP) image set derived from a 4D CT-via an axial CMR image set, using rigid image registration focused on the target area. The cardiac and the respiratory motion of the target were resolved using ciné-CMR and 4D CT imaging studies, respectively.
The workflow was carried out for 6 patients and resulted in an internal target defined in standard anatomical orientation that encompassed the cardiac and the respiratory motion of the initial target.
An image registration-based workflow was implemented to render the STAR target on the planning image set in a consistent manner, using commercial software traditionally available for radiation therapy.
在立体定向心律失常放射性消融(STAR)中,使用多模态影像学研究和由电生理学家、心脏病学家、心脏放射科医生和放射肿瘤学家组成的多学科团队来定义目标,并协作确定目标并在相关影像学研究上勾画目标。本报告描述了我们放射治疗部门采用的工作流程,以便将基于电生理和心脏病学成像确定的目标转移到治疗计划图像集上。
放射治疗团队首先在心脏轴位上呈现初始目标,在宽频带延迟钆增强(WB-LGE)心脏磁共振(CMR)研究上进行勾画,然后通过刚性图像配准将其转移到用于治疗计划的计算机断层扫描(CT)-即从 4D CT 衍生的平均强度投影(AIP)图像集,该配准通过关注目标区域的轴向 CMR 图像集来实现。使用电影式 CMR 和 4D CT 成像研究分别解决了目标的心脏和呼吸运动。
该工作流程在 6 名患者中进行,结果生成了一个以标准解剖方位定义的内部目标,该目标包含了初始目标的心脏和呼吸运动。
我们实施了一种基于图像配准的工作流程,使用传统上可用于放射治疗的商业软件,以一致的方式在计划图像集上呈现 STAR 目标。