Metzger M
Dermatol Monatsschr. 1979 Apr;165(4):257-63.
Numerous investigators tried over the years to induce artifically immunity against syphilis by use of a variety of treponema preparations. None of these immunization experiments performed by different means and routes provided clear evidence of acquired immunity in animals and humans given various vaccine preparations against challenge with even minimal doses of virulent T. pallidum. In recent years, however, promising results have been obtained in the immunization study. Two types of syphilis vaccine have been developed which were found very effective in conferring a protection against syphilitic infection on rabbits: (1) the first vaccine contains T. pallidum attenuated by gamma irradiation, and the other one (2) contains T. pallidum killed by penicillin. In addition, it has been demonstrated that the immunogenic activity of T. pallidum is related to their very labile protein component. Pretty much is also known on the factors influencing the immune response of artificially immunized rabbits, and on the immunological mechanisms underlying the development of syphilis immunity.
多年来，众多研究人员试图通过使用各种密螺旋体制剂来人工诱导抗梅毒免疫力。这些通过不同方法和途径进行的免疫实验，没有一个能为接种各种疫苗制剂的动物和人类提供明确的证据，证明其在面对哪怕极小剂量的毒力苍白密螺旋体攻击时获得了免疫力。然而，近年来在免疫研究中取得了令人鼓舞的结果。已开发出两种梅毒疫苗，它们在保护兔子免受梅毒感染方面非常有效：（1）第一种疫苗含有经γ射线辐照减毒的苍白密螺旋体，另一种（2）含有被青霉素杀死的苍白密螺旋体。此外，已证明苍白密螺旋体的免疫原活性与其非常不稳定的蛋白质成分有关。对于影响人工免疫兔子免疫反应的因素以及梅毒免疫发展的免疫机制也有了相当多的了解。
