Ionescu D, Georgescu M
Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Bacteriol Virusol Parazitol Epidemiol. 1979 Apr-Jun;24(2):81-96.
Until lately, the host-parasite relationship in syphilis registered a certain latency because of the difficult approach to the problem and especially because of the enthusiasm caused by the possible eradication of the disease by penicillin. As these expectations were not confirmed, attention was again focussed on study by modern means of the biology of pathogenic treponema, its antigenic properties, possibility of in vitro cultivation and certain humoral and cellular immune aspects that govern the evolution of the disease and, probable, the acquiring of specific immunity. The attempts made for obtaining a live vaccine, attenuated by irradiation and experimented in animals, appear to foreshadow the possible use of this vaccine in the near future in man.
直到最近，由于研究梅毒宿主-寄生虫关系问题的方法困难，尤其是由于青霉素可能根除该病所引发的热情，该关系一直存在一定潜伏期。由于这些期望未得到证实，人们再次将注意力集中于通过现代手段研究致病性密螺旋体的生物学特性、其抗原特性、体外培养的可能性以及某些体液和细胞免疫方面，这些方面决定了疾病的发展，可能还决定了特异性免疫的获得。通过辐射减毒并在动物身上进行试验以获得活疫苗的尝试，似乎预示着这种疫苗在不久的将来有可能用于人体。
