Metzger M, Podwińska J, Smogór W
Arch Immunol Ther Exp (Warsz). 1977;25(1):25-34.
The development of cell-mediated immunity was studied in rabbits: a) experimentally injected with T. pallidum, and b) artificially immunized with nonviable T. pallidum. The macrophage migration inhibition test (MMI test) using ultrasonicate of T. pallidum as antigen was employed to demonstrate this type of immunologic response. Lymphocytes of syphilitic rabbits were found to exert a pronounced inhibitory effect upon macrophage migration as early as one month after infection; between the fourth and sixth month, a transient decrease of this capacity occurred, followed by a slow but steady increase during the next two years, i.e. until the end of the observation period. In rabbits in which the infection had been controlled by penicillin treatment in the fifth month, no increase but gradual diminution of this capacity was observed. In the group of rabbits artificially immunized with nonviable T. pallidum, the MMI response appeared very shortly after commencement of the immunization and persisted for about nine months after completion of the immunization procedure. Only a crude correlation could be established between levels of the MMI response of the immunized animals and their resistance to infection with T. pallidum.
a）通过实验注射梅毒螺旋体，以及b）用灭活的梅毒螺旋体进行人工免疫。采用以梅毒螺旋体超声提取物为抗原的巨噬细胞移动抑制试验（MMI试验）来证明这种免疫反应类型。发现感染梅毒的兔子的淋巴细胞早在感染后一个月就对巨噬细胞移动产生显著的抑制作用；在第四至第六个月期间，这种能力出现短暂下降，随后在接下来的两年里缓慢但持续增加，即直到观察期结束。在第五个月用青霉素治疗控制了感染的兔子中，未观察到这种能力增加，而是逐渐减弱。在用灭活的梅毒螺旋体进行人工免疫的兔子组中，MMI反应在免疫开始后很快出现，并在免疫程序完成后持续约九个月。免疫动物的MMI反应水平与其对梅毒螺旋体感染的抵抗力之间只能建立粗略的相关性。
