昼夜节律周期与神经炎症。
Circadian cycle and neuroinflammation.
作者信息
Xu Xinzi, Wang Junli, Chen Guohua
机构信息
College of Clinical Chinese Medicine, Hubei University of Chinese Medicine, Wuhan 430065, China.
Department of Neurology, Wuhan No. 1 Hospital, Wuhan 430022, China.
出版信息
Open Life Sci. 2023 Oct 17;18(1):20220712. doi: 10.1515/biol-2022-0712. eCollection 2023.
Abstract
Circadian cycle is a fundamental characteristic of life formed in the long-term evolution of organisms and plays an important role in maintaining the proliferation, migration, and activation of immune cells. Studies have shown that circadian rhythm disorders affect the occurrence and development of neuroinflammation by inducing glial cell activation and peripheral immune responses. In this article, we briefly described the research progress of neuroinflammation and circadian rhythm in recent years and explored the effects and possible mechanism of circadian rhythmicity on microglia, astrocytes, and peripheral immune function.
摘要
昼夜节律是生物体在长期进化过程中形成的基本生命特征，在维持免疫细胞的增殖、迁移和激活中发挥重要作用。研究表明，昼夜节律紊乱通过诱导胶质细胞活化和外周免疫反应影响神经炎症的发生和发展。在本文中，我们简要描述了近年来神经炎症和昼夜节律的研究进展，并探讨了昼夜节律对小胶质细胞、星形胶质细胞和外周免疫功能的影响及可能机制。
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