Yoo Changyoung, Kang Seongmin, Choi Seong-Wook
Interdisciplinary Program in Biohealth-Machinery Convergence Engineering, Kangwon National University, Chuncheon-si, 24341 Republic of Korea.
Program of Mechanical and Biomedical Engineering, College of Engineering, Chuncheon-si, 24341 Republic of Korea.
Biomed Eng Lett. 2023 Jun 6;13(4):681-688. doi: 10.1007/s13534-023-00295-7. eCollection 2023 Nov.
Extracorporeal membrane oxygenation device is a procedure in which mechanical systems circulate blood and supply oxygen to patients with impaired cardiopulmonary function. Current venoarterial systems are associated with low patient survival rates and new treatments are needed to avoid left ventricular dilation, which is a major cause of death. In this study, a new mobile pulsatile ECMO with a pump structure that supplies pulsatile flow by using an oxygen tank as a power source is proposed. In vitro experiments conducted under mock circulation system as like patient conditions demonstrated that 2.8 L oxygen can sustain the outflow of 1 L/min of pulsatile blood flow for 53 min, while a 4.6 L tank was able to sustain the same flow for 85 min. The energy equivalent pressure evaluation index of the pulsatile blood pump shows that the mobile pulsatile ECMO could supply sufficient pulsatile blood flow compared to the existing pulsatile ECMO. Through in vitro experiments performed under mock circulation conditions, this new system was proven to supply sufficient oxygen and pulsatile blood flow using the pressure of an oxygen tank even while transporting a patient.
体外膜肺氧合装置是一种利用机械系统为心肺功能受损的患者循环血液并提供氧气的治疗手段。目前的静脉 - 动脉系统患者生存率较低，需要新的治疗方法来避免左心室扩张，而左心室扩张是主要死因。在本研究中，提出了一种新型的可移动搏动性体外膜肺氧合装置，其泵结构利用氧气罐作为动力源来提供搏动血流。在模拟患者条件的体外循环系统下进行的实验表明，2.8升氧气能够维持1升/分钟的搏动血流流出53分钟，而4.6升的氧气罐能够维持相同血流85分钟。搏动血泵的能量等效压力评估指标表明，与现有的搏动性体外膜肺氧合装置相比，这种可移动搏动性体外膜肺氧合装置能够提供足够的搏动血流。通过在模拟循环条件下进行的体外实验，证明了即使在转运患者时，该新系统利用氧气罐的压力也能提供足够的氧气和搏动血流。
