Weng Qi, Zhang Feng, Zheng Quan
Quzhou People's Hospital The Quzhou Affiliated Hospital of Wenzhou Medical University Quzhou China.
Department of Pharmacy Quzhou People's Hospital The Quzhou Affiliated Hospital of Wenzhou Medical University Quzhou China.
MedComm (2020). 2023 Oct 21;4(6):e402. doi: 10.1002/mco2.402. eCollection 2023 Dec.
The molecular mechanism of N-methylguanosine (mG)-tRNA modification mediated by the methyltransferase like 1-WD repeat domain 4 (METTL1-WDR4). Route A indicated that with WDR4 as the scaffold, METTL1 catalyzed G46 methylation modification after binding of the tRNA variable loop via its αC and α6 helices, as reported by Richard I. Gregory's group. Route B showed the METTL1-WDR4-mediated tRNA methylation modification model and the effect of binding of the -adenosylmethionine on the N-terminus of METTL1, as reported by Yunsun Nam's group.
由类甲基转移酶1- WD重复结构域4（METTL1-WDR4）介导的N-甲基鸟苷（mG）-tRNA修饰的分子机制。途径A表明，如理查德·I·格雷戈里团队所报道，以WDR4为支架，METTL1通过其αC和α6螺旋与tRNA可变环结合后催化G46甲基化修饰。途径B展示了METTL1-WDR4介导的tRNA甲基化修饰模型以及腺苷甲硫氨酸与METTL1 N端结合的作用，如尹孙南团队所报道。
