Stojic Vladislava, Zdravkovic Natasa, Nikolic-Turnic Tamara, Zdravkovic Nebojsa, Dimitrijevic Jelena, Misic Aleksandra, Jovanovic Kristijan, Milojevic Stefan, Zivic Jelena
Department of Medical Statistics and Informatics, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Department of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Open Med (Wars). 2023 Oct 17;18(1):20230811. doi: 10.1515/med-2023-0811. eCollection 2023.
The aim of this study was to evaluate the efficacy of endoscopic polypectomy as a therapeutic treatment for malignant alteration of colorectal polyps. In a 5-year research, 89 patients were included, who were tested and treated at the University Clinical Center Kragujevac, Kragujevac, Serbia, with the confirmed presence of malignant alteration polyps of the colon by colonoscopy, which were removed using the method of endoscopic polypectomy and confirmed by the histopathological examination of the entire polyp. After that, the same group of patients was monitored endoscopically within a certain period, controlling polypectomy locations and the occurrence of a possible remnant of the polyp, in the period of up to 2 years of polypectomy. We observed that, with an increasing size of polyps, there is also an increase in the percentage of the complexity of endoscopic resection and the appearance of remnant with histological characteristics of the invasive cancer. The highest percentage of incomplete endoscopic resection and the appearance of remnant with histological characteristics of the invasive cancer were shown at malignant altered polyps in the field of tubulovillous adenoma. Eighteen patients in total underwent the surgical intervention. In conclusion, our data support the high efficacy of endoscopic polypectomy for the removal of the altered malignant polyp.
本研究的目的是评估内镜下息肉切除术作为治疗大肠息肉恶变的疗效。在一项为期5年的研究中，纳入了89例患者，这些患者在塞尔维亚克拉古耶瓦茨大学临床中心接受检查和治疗，经结肠镜检查确诊存在结肠恶变息肉，采用内镜下息肉切除术将其切除，并通过对整个息肉进行组织病理学检查予以证实。之后，在息肉切除术后长达2年的时间内，对同一组患者进行内镜监测，观察息肉切除部位以及是否可能存在息肉残留。我们观察到，随着息肉尺寸的增大，内镜切除的复杂程度百分比以及具有浸润性癌组织学特征的残留息肉的出现率也随之增加。在管状绒毛状腺瘤区域的恶变息肉中，内镜切除不完全以及出现具有浸润性癌组织学特征残留息肉的百分比最高。共有18例患者接受了手术干预。总之，我们的数据支持内镜下息肉切除术在切除恶变息肉方面具有很高的疗效。
