Pharmaceutical Department, Ercolano, Naples, Italy.
Sanitary District, Pompei, Naples, Italy.
Nutr Cancer. 2023;75(10):1848-1862. doi: 10.1080/01635581.2023.2272343. Epub 2023 Nov 30.
Obesity, a complex and multifactorial disease influenced by genetic, environmental, and psychological factors, has reached epidemic proportions globally, posing a significant health challenge. In addition to its established association with cardiovascular disease and type II diabetes, obesity has been implicated as a risk factor for various cancers. However, the precise biological mechanisms linking obesity and cancer remain largely understood. Adipose tissue, an active endocrine organ, produces numerous hormones and bioactive molecules known as adipokines, which play a crucial role in metabolism, immune responses, and systemic inflammation. Notably, adiponectin (APN), the principal adipocyte secretory protein, exhibits reduced expression levels in obesity. In this scoping review, we explore and discuss the role of APN in influencing cancer in common malignancies, including lung, breast, colorectal, prostate, gastric, and endometrial cancers. Our review aims to emphasize the critical significance of investigating this field, as it holds great potential for the development of innovative treatment strategies that specifically target obesity-related malignancies. Furthermore, the implementation of more rigorous and comprehensive prevention and treatment policies for obesity is imperative in order to effectively mitigate the risk of associated diseases, such as cancer.
肥胖是一种复杂的多因素疾病，受遗传、环境和心理因素的影响，在全球范围内已达到流行程度，对健康构成了重大挑战。除了与心血管疾病和 2 型糖尿病的既定关联外，肥胖也被认为是多种癌症的危险因素。然而，肥胖与癌症之间的确切生物学机制在很大程度上仍未被理解。脂肪组织是一种活跃的内分泌器官，它产生许多被称为脂肪因子的激素和生物活性分子，这些分子在代谢、免疫反应和全身炎症中发挥着关键作用。值得注意的是，脂联素（APN）是主要的脂肪细胞分泌蛋白，在肥胖症中表达水平降低。在本次范围综述中，我们探讨并讨论了 APN 在影响常见恶性肿瘤（包括肺癌、乳腺癌、结直肠癌、前列腺癌、胃癌和子宫内膜癌）中癌症的作用。我们的综述旨在强调研究这一领域的重要性，因为它为开发专门针对肥胖相关恶性肿瘤的创新治疗策略提供了巨大的潜力。此外，必须实施更严格和全面的肥胖预防和治疗政策，以有效降低相关疾病（如癌症）的风险。
