Department of Family and Community Medicine, College of Medicine, Taibah University, Al-Madinah al-Munawwarah 42353, Saudi Arabia.
Med Sci (Basel). 2023 Oct 1;11(4):63. doi: 10.3390/medsci11040063.
There are several risk factors attributed to tuberculosis (TB) mortality and morbidity. There are few studies and systematic reviews showing the association of silicosis and tuberculosis at a country level. Very limited studies have been conducted using multi-country data in studying the association of incidence of silicosis with TB mortality and morbidity. Hence, the aim of this research was to explore the association of incidence of silicosis and other important risk factors with TB mortality and morbidity using multi-country data.
Data from 217 WHO region countries were utilized, sourcing TB-related statistics from the Institute of Health Metrics and Evaluation and additional risk factors from the Demographic and Health Survey, Global Burden of Disease, and World Bank for 2019. Regression analysis was conducted to examine the association between silicosis incidence and TB outcomes.
The study found an average silicosis incidence of 121.92 per 100,000 population. Additionally, 62.69% of the sample population are exposed to air pollution from solid fuel cooking. Sanitation access stands at an average of 59.67%. Regression outcomes indicate that while alcohol consumption's influence on TB is not statistically significant, a unit increase in silicosis incidence significantly elevates TB deaths (235.9, = 0.005), YLL (9399.3, = 0.011), and YLD (910.8, = 0.002).
The burden of silicosis is found to be one of the important determinants of deaths, YLL, and YLD due to tuberculosis. Country-specific strategies to prevent and control silicosis is a need of the hour.
有几个与结核病（TB）死亡率和发病率相关的风险因素。很少有研究和系统评价显示矽肺与国家一级结核病之间的关联。使用多国家数据研究矽肺发病率与结核病死亡率和发病率之间的关系的研究非常有限。因此，本研究的目的是利用多国家数据探讨矽肺发病率和其他重要风险因素与结核病死亡率和发病率之间的关系。
利用来自世卫组织区域 217 个国家的数据，从卫生计量与评估研究所获取与结核病相关的统计数据，并从人口与健康调查、全球疾病负担和世界银行获取 2019 年其他风险因素的数据。采用回归分析来检验矽肺发病率与结核病结果之间的关系。
研究发现，平均每 10 万人中有 121.92 人患有矽肺。此外，62.69%的样本人口暴露于固体燃料烹饪产生的空气污染中。卫生设施的普及率平均为 59.67%。回归结果表明，尽管饮酒对结核病的影响没有统计学意义，但矽肺发病率每增加一个单位，结核病死亡人数（235.9， = 0.005）、YLL（9399.3， = 0.011）和 YLD（910.8， = 0.002）都会显著升高。
矽肺的负担被认为是结核病死亡、YLL 和 YLD 的重要决定因素之一。各国需要制定具体的预防和控制矽肺的策略。
