Sekine Airi, Nakajima Kei
Department of Food and Nutrition, Faculty of Human Sciences and Design, Japan Women's University, Tokyo 112-8681, Japan.
Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University, Kawagoe 350-8550, Japan.
Epidemiologia (Basel). 2023 Oct 2;4(4):370-381. doi: 10.3390/epidemiologia4040034.
The Japanese National Database (NDB), a useful data source for epidemiological studies, contains information on health checkups, disease diagnoses, and medications, which can be used when investigating common cardiometabolic diseases. However, before the initiation of an integrated analysis, we need to combine several pieces of information prepared separately into an all-in-one dataset (AIOD) and confirm the validation of the dataset for the study. In this study, we aimed to confirm the degree of agreement in data entries between diagnoses and prescribed medications and self-reported pharmacotherapy for common cardiometabolic diseases in newly assembled AIODs. The present study included 10,183,619 people who underwent health checkups from April 2018 to March 2019. Over 95% of patients prescribed antihypertensive and antidiabetic medications were diagnosed with each disease. For dyslipidemia, over 95% of patients prescribed medications were diagnosed with at least one of the following: dyslipidemia, hypercholesterolemia, or hyperlipidemia. Similarly, over 95% of patients prescribed medications for hyperuricemia were diagnosed with either hyperuricemia or gout. Additionally, over 90% of patients with self-reported medications for hypertension, diabetes, and dyslipidemia were diagnosed with each disease, although the proportions differed among age groups. Our study demonstrated high levels of agreement between diagnoses and prescribed medications for common cardiometabolic diseases and self-reported pharmacotherapy in our AIOD.
日本国家数据库（NDB）是流行病学研究的一个有用数据源，包含健康检查、疾病诊断和用药信息，在调查常见心脏代谢疾病时可加以利用。然而，在开始进行综合分析之前，我们需要将分别准备的几条信息合并到一个一体化数据集（AIOD）中，并确认该数据集对研究的有效性。在本研究中，我们旨在确认新组装的AIOD中常见心脏代谢疾病的诊断与处方药物以及自我报告的药物治疗之间的数据录入一致程度。本研究纳入了2018年4月至2019年3月期间接受健康检查的10183619人。超过95%开具抗高血压和抗糖尿病药物的患者被诊断患有相应疾病。对于血脂异常，超过95%开具药物的患者被诊断患有以下至少一种疾病：血脂异常、高胆固醇血症或高脂血症。同样，超过95%开具高尿酸血症药物的患者被诊断患有高尿酸血症或痛风。此外，超过90%自我报告患有高血压、糖尿病和血脂异常药物的患者被诊断患有相应疾病，尽管各年龄组的比例有所不同。我们的研究表明，在我们的AIOD中，常见心脏代谢疾病的诊断与处方药物以及自我报告的药物治疗之间具有高度一致性。
