Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA.
J Vet Intern Med. 2023 Nov-Dec;37(6):2119-2124. doi: 10.1111/jvim.16907. Epub 2023 Oct 24.
Gastric hyperacidity and hypergastrinemia are purported to cause gastric ulceration in dogs with chronic kidney disease (CKD); however, no published studies have evaluated gastric pH with serum gastrin concentrations in dogs with CKD.
To compare mean intragastric pH, mean percent pH distribution, and serum gastrin concentrations in dogs with CKD to age-matched, healthy dogs. We hypothesized there would be no difference in mean gastric pH or serum gastrin between groups.
Thirteen dogs with CKD; 10 aged-matched healthy dogs.
Prospective, case-control study. Serum chemistry, complete blood count, urinalysis, and serum gastrin concentrations were evaluated in all dogs before radiographic-assisted gastric placement of a pH capsule. Forty-eight-hour continuous gastric pH monitoring was performed in all dogs. Serum gastrin concentration, mean pH, and mean percentage time that gastric pH was strongly acidic (pH <1 and pH <2) were compared between groups using a repeated measures mixed-model ANOVA.
No significant differences were observed between groups for any pH measurements, including mean ± SD gastric pH (CKD, 2.37 ± 0.87; healthy, 2.39 ± 0.99; P > .05). Serum gastrin concentrations were not significantly different between groups (median [range]: CKD, 10.5 ng/dL [<10-17.1]; healthy, 10.9 ng/dL [<10-15]; P > .05).
Our client-owned dogs with CKD did not have lower gastric pH or higher serum gastrin concentrations compared to healthy dogs. Our results suggest that prophylactic gastric acid suppression in dogs with CKD is not warranted unless other clinical indications for use are present.
胃酸过多和高胃泌素血症被认为会导致患有慢性肾病（CKD）的犬发生胃溃疡；然而，目前尚无研究评估 CKD 犬的胃 pH 值与血清胃泌素浓度之间的关系。
比较 CKD 犬与年龄匹配的健康犬的平均胃内 pH 值、平均 pH 值分布百分比和血清胃泌素浓度。我们假设两组间的平均胃 pH 值或血清胃泌素值无差异。
13 只 CKD 犬；10 只年龄匹配的健康犬。
前瞻性病例对照研究。所有犬均在放射辅助下放置 pH 胶囊前进行血清生化、全血细胞计数、尿液分析和血清胃泌素浓度检测。所有犬均进行 48 小时连续胃 pH 监测。使用重复测量混合模型方差分析比较两组间的血清胃泌素浓度、平均 pH 值和胃 pH 值呈强酸性（pH <1 和 pH <2）的平均时间百分比。
两组间任何 pH 测量值均无显著差异，包括平均胃 pH 值（±SD）（CKD 组，2.37 ± 0.87；健康对照组，2.39 ± 0.99；P >.05）。两组间的血清胃泌素浓度无显著差异（中位数[范围]：CKD 组，10.5ng/dL [10-17.1]；健康对照组，10.9ng/dL [10-15]；P >.05）。
与健康犬相比，我们的 CKD 患犬的胃 pH 值并未降低，血清胃泌素浓度也未升高。我们的结果表明，除非存在其他使用临床指征，否则 CKD 犬无需预防性抑酸。
