奥美拉唑长效注射剂在健康犬体内的评价。
Evaluation of a long-acting injectable formulation of omeprazole in healthy dogs.
机构信息
Department of Small Animal Clinical Sciences, University of Florida, Gainesville, Florida, USA.
Department of Small Animal Clinical Sciences, University of Tennessee, Knoxville, Tennessee, USA.
出版信息
J Vet Intern Med. 2022 Jul;36(4):1416-1421. doi: 10.1111/jvim.16440. Epub 2022 May 12.
BACKGROUND
To evaluate the efficacy of a single intramuscular adminsitration of long-acting omeprazole (LA-OMEP) in increasing gastric pH in dogs.
HYPOTHESIS
We hypothesized that LA-OMEP would meet in healthy dogs the clinical goals defined for human patients for treatment of gastroduodenal ulceration.
ANIMALS
Nine healthy research dogs.
METHODS
Prospective experimental study. Dogs were given a 4 mg/kg intramuscular injection of LA-OMEP. Intragastric pH was continuously recorded on treatment days 0 to 7. Daily mean pH and mean percentage time (MPT) intragastric pH was ≥3 or ≥4 were determined.
RESULTS
The mean onset of action for the LA-OMEP was 98.11 min (SD 46.39). The mean number of days the dogs' pH met established goals for MPT pH ≥3 was 5.5 days (range, 3-7) and 5.25 days for MPT pH ≥4 (range, 3-7). Long-acting omeprazole met the human clinical goals pH ≥3 for 72 hours in 8/8 of the dogs and MPT pH ≥4 for 96 hours in 7/8 of dogs.
CONCLUSIONS AND CLINICAL IMPORTANCE
The LA-OMEP formulation produced gastric acid suppression in healthy dogs for an average of 5 days and up to 7 days, after a single intramuscular injection. No major adverse effects were observed.
背景
评估长效奥美拉唑（LA-OME）单次肌内给药在提高犬胃内 pH 值方面的疗效。
假说
我们假设 LA-OME 将在健康犬中满足人类患者治疗胃十二指肠溃疡的临床目标。
动物
9 只健康研究犬。
方法
前瞻性实验研究。犬给予 4mg/kg 的 LA-OME 肌内注射。在治疗第 0 至 7 天连续记录胃内 pH 值。确定每日平均 pH 值和平均时间百分比（MPT）胃内 pH 值≥3 或≥4。
结果
LA-OME 的平均作用时间为 98.11 分钟（SD 46.39）。犬 pH 值符合 MPT pH 值≥3 的设定目标的天数平均为 5.5 天（范围为 3-7 天），MPT pH 值≥4 的天数平均为 5.25 天（范围为 3-7 天）。长效奥美拉唑在 8/8 只犬中满足人类临床目标 pH 值≥3 达 72 小时，在 7/8 只犬中满足 MPT pH 值≥4 达 96 小时。
结论和临床意义
单次肌内注射 LA-OME 制剂可使健康犬的胃酸抑制作用平均持续 5 天，最长可达 7 天。未观察到主要不良反应。
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