Du Min, Zhang Jianing, Jin Jing, Jiang Wei
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.
School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, P. R. China.
ACS Biomater Sci Eng. 2023 Nov 13;9(11):6103-6111. doi: 10.1021/acsbiomaterials.3c01135. Epub 2023 Oct 24.
Poly(styrene--(ethylene--butylene)--styrene) (SEBS) with eminent elasticity, thermoplastic ability, and biological stability has aroused great interest in the medical area. However, bacteria can easily adhere to the hydrophobic SEBS surface to cause medical device-related infections. In this work, SEBS is modified to prepare the SEBS-polydopamine (PDA)-poly(lysine) quaternary ammonium derivative (PLQ) antibacterial surface by PDA deposition and surface grafting techniques to solve bacterial infections. PDA is used as an intermediate layer and presents an excellent photothermal effect. The grafted polymer PLQ has antimicrobial quaternary ammonium cation groups, which plays synergistic bactericidal therapy with PDA. The SEBS-PDA-PLQ surface almost totally suppresses the growth of bacteria with a surface bacterial survival rate of 0.05% under laser irradiation. The outstanding antibacterial activity of the SEBS-PDA-PLQ surface is attributed to the synergistic effects of the photothermal performance of PDA and quaternary ammonium cationic functional groups of PLQ. In addition, the membrane SEBS-PDA-PLQ shows good hydrophilicity, antiprotein adsorption ability, chemical stability, and biocompatibility. This antibiotic-free antimicrobial approach has great potential for practical application in solving infections associated with medical devices.
具有卓越弹性、热塑性能和生物稳定性的聚（苯乙烯-（乙烯-丁烯）-苯乙烯）（SEBS）在医学领域引起了极大的关注。然而，细菌很容易附着在疏水性的SEBS表面，从而导致与医疗器械相关的感染。在这项工作中，通过多巴胺（PDA）沉积和表面接枝技术对SEBS进行改性，制备了SEBS-聚多巴胺（PDA）-聚赖氨酸季铵衍生物（PLQ）抗菌表面，以解决细菌感染问题。PDA用作中间层，并呈现出优异的光热效应。接枝聚合物PLQ具有抗菌季铵阳离子基团，可与PDA协同进行杀菌治疗。在激光照射下，SEBS-PDA-PLQ表面几乎完全抑制了细菌的生长，表面细菌存活率为0.05%。SEBS-PDA-PLQ表面出色的抗菌活性归因于PDA的光热性能与PLQ的季铵阳离子官能团的协同作用。此外，SEBS-PDA-PLQ膜表现出良好的亲水性、抗蛋白吸附能力、化学稳定性和生物相容性。这种无抗生素的抗菌方法在解决与医疗器械相关的感染方面具有巨大的实际应用潜力。
