Jiangsu Key Laboratory for Microbes and Functional Genomics, Engineering and Technology Research Center for Microbiology, College of Life Sciences, Nanjing Normal University , Nanjing, Jiangsu, China.
Department of Bioinformatics, School of Life Sciences, Xuzhou Medical University , Xuzhou, Jiangsu, China.
Appl Environ Microbiol. 2023 Nov 29;89(11):e0117023. doi: 10.1128/aem.01170-23. Epub 2023 Oct 24.
Calcium ions are ubiquitous intracellular signaling molecules for many signaling pathways regulating the fungal response to stress and antifungal drugs. The concentration of intracellular calcium is tightly regulated in its storage, release, and distribution. CrzA is the best-studied transcription factor that regulates this process under sufficient calcium or other external signals. However, CrzA was excluded from nuclei and then lost transcriptional activation under calcium-limited conditions. The regulators in the Ca signaling pathway under calcium-limited conditions remain unclear. Here, we identified SltA as a key regulator in the Ca signaling pathway under calcium-limited conditions, and the underlying mechanisms were further explored in . These findings reveal a transcriptional control pathway that precisely regulates calcium homeostasis under calcium-limited conditions.
钙离子是许多信号通路中普遍存在的细胞内信号分子，调节真菌对压力和抗真菌药物的反应。细胞内钙离子的浓度在其储存、释放和分布方面受到严格调节。CrzA 是研究最充分的转录因子，它在充足的钙或其他外部信号下调节这个过程。然而，在钙离子有限的条件下，CrzA 被排除在核外，从而失去转录激活。在钙离子有限的条件下，Ca 信号通路中的调节剂尚不清楚。在这里，我们鉴定出 SltA 是钙离子有限条件下 Ca 信号通路中的关键调节剂，并进一步在 中探讨了其潜在机制。这些发现揭示了一个在钙离子有限的条件下精确调节钙稳态的转录控制途径。
