体重减轻百分比与心血管健康评分之间的倒 U 型关系。

The inverted U-shaped relationship between weight loss percentage and cardiovascular health scores.

机构信息

Department of Child Healthcare, Wenzhou People's Hospital, Wenzhou, 325000, China.

出版信息

Eat Weight Disord. 2023 Oct 24;28(1):87. doi: 10.1007/s40519-023-01619-3.

DOI:10.1007/s40519-023-01619-3

PMID:37874416

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10598164/

Abstract

PURPOSE

Obesity is a significant risk factor for cardiovascular disease; however, the impact of weight loss on cardiovascular health (CVH) in individuals with specific obesity patterns remains incompletely understood. The objective of our study was to investigate the relationship weight loss percentage and CVH scores across individuals with various obesity patterns.

METHODS

Our study utilized data from the National Health and Nutrition Examination Survey conducted between 2007 and 2018, involving a total of 12,835 participants aged 16 years or older, to conduct a cross-sectional analysis. Multiple linear regression and multinomial logistic regression methods were used to assess the correlation between the weight loss percentage and the CVH scores. Additionally, restricted cubic spline analysis was employed to examine the nonlinear relationship between the two variables.

RESULTS

Compared to individuals with a weight loss percentage < 0%, participants with weight loss percentages of 0-5% and 5.1-10% showed improved CVH scores, with β values of 2.85 (95% CI 2.32-3.38) and 2.55 (95% CI 1.69-3.4), respectively. Regarding different obesity patterns, compared to participants with a weight loss percentage < 0%, participants with a weight loss percentage of 0-5% showed an increase in CVH scores in the normal weight and overweight/general obesity (OGO) groups, with β values of 1.45 (95% CI 0.7-2.19) and 1.22 (95% CI 0.46-1.97), respectively. Restricted cubic spline analysis revealed a significant inverted U-shaped relationship between the weight loss percentage and the CVH scores (with optimal CVH scores at 3%).

CONCLUSIONS

There was an inverted U-shaped relationship between weight loss percentage and CVH scores, with moderate weight loss (0-10%, optimal value of 3%) being associated with improved CVH scores, especially among individuals with OGO.

LEVEL V

Opinions of respected authorities, based on descriptive studies, narrative reviews, clinical experience, or reports of expert committees.

摘要

目的

肥胖是心血管疾病的一个重要危险因素；然而，对于具有特定肥胖模式的个体，体重减轻对心血管健康（CVH）的影响仍不完全清楚。我们的研究目的是调查不同肥胖模式个体的体重减轻百分比与 CVH 评分之间的关系。

方法

我们的研究利用了 2007 年至 2018 年期间进行的国家健康和营养检查调查的数据，共涉及 12835 名 16 岁或以上的参与者，进行了横断面分析。使用多元线性回归和多项逻辑回归方法评估体重减轻百分比与 CVH 评分之间的相关性。此外，还使用限制立方样条分析来检查这两个变量之间的非线性关系。

结果

与体重减轻百分比<0%的个体相比，体重减轻百分比为 0-5%和 5.1-10%的个体 CVH 评分有所改善，β值分别为 2.85（95%置信区间 2.32-3.38）和 2.55（95%置信区间 1.69-3.4）。关于不同的肥胖模式，与体重减轻百分比<0%的个体相比，体重减轻百分比为 0-5%的个体在正常体重和超重/一般性肥胖（OGO）组中 CVH 评分有所增加，β值分别为 1.45（95%置信区间 0.7-2.19）和 1.22（95%置信区间 0.46-1.97）。限制立方样条分析显示，体重减轻百分比与 CVH 评分之间存在显著的倒 U 型关系（最佳 CVH 评分在 3%）。