正常受试者中采用相似技术对鼻腔与气管支气管清除功能的比较。
Comparison of nasal and tracheobronchial clearance by similar techniques in normal subjects.
作者信息
Millar A B, Agnew J E, Newman S P, Lopez-Vidriero M T, Pavia D, Clarke S W
出版信息
Thorax. 1986 Oct;41(10):783-6. doi: 10.1136/thx.41.10.783.
Nasal and tracheobronchial mucociliary clearance have been compared in 10 healthy subjects. Nasal clearance was measured by monitoring the rate of removal of 2 microns diameter Teflon particles, labelled with 99mTc, which had been placed in the anterior part of the nose. Tracheobronchial clearance was measured with an objective radioaerosol technique, 5 microns diameter polystyrene particles being used. With these comparable techniques there was a close correlation between the nasal mucociliary clearance rate and both the area under the tracheobronchial clearance curve from 0 to 6 hours after radioaerosol inhalation (rs = -0.94, p less than 0.001) and the area under the tracheobronchial clearance curve from 0 to 2.5 hours after inhalation (rs = -0.79, p less than 0.01). The rate of clearance of small particles from the nose may thus be a useful guide to tracheobronchial clearance in healthy individuals.
对10名健康受试者的鼻腔和气管支气管黏液纤毛清除功能进行了比较。通过监测置于鼻前部的、用99mTc标记的直径2微米的聚四氟乙烯颗粒的清除速率来测量鼻腔清除功能。采用客观的放射性气溶胶技术测量气管支气管清除功能，使用的是直径5微米的聚苯乙烯颗粒。运用这些可比较的技术，鼻腔黏液纤毛清除速率与放射性气溶胶吸入后0至6小时气管支气管清除曲线下面积（rs = -0.94，p < 0.001）以及吸入后0至2.5小时气管支气管清除曲线下面积（rs = -0.79，p < 0.01）之间均存在密切相关性。因此，健康个体中鼻腔小颗粒的清除速率可能是气管支气管清除功能的一个有用指标。
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