Department of Botany, Panjab University, Chandigarh, India.
Plant Signal Behav. 2023 Dec 31;18(1):2273593. doi: 10.1080/15592324.2023.2273593. Epub 2023 Oct 24.
Hypoxia triggers reactive oxygen species (ROS)-induced elevation in cytoplasmic calcium (Ca) in the plant cells. Calcium-dependent protein kinase 12 (CPK12) acts as a sensor to recognize the Ca signature and is activated by autophosphorylation. Then, the CPK12 moves into the nucleus with the help of phosphatidic acid (PA) and phosphorylates ERF-VII family proteins that activate hypoxia signaling and response. The study provides a novel mechanism of hypoxia signaling in plants. Moreover, the mechanism of hypoxia-specific Ca signature generation remains elusive.
缺氧会触发植物细胞中活性氧（ROS）诱导的细胞质钙（Ca）升高。钙依赖蛋白激酶 12（CPK12）作为传感器识别 Ca 特征，并通过自身磷酸化而被激活。然后，CPK12 在磷酸脂酸（PA）的帮助下进入细胞核，并磷酸化激活低氧信号和反应的 ERF-VII 家族蛋白。该研究为植物中的低氧信号提供了一种新的机制。此外，低氧特异性 Ca 特征生成的机制仍不清楚。
