Department of Special Surgery, Faculty of Medicine, Hashemite University, Zarqa, Jordan.
Department of Pediatrics, New Zarqa Governmental Hospital, Zarqa, Jordan.
Am J Case Rep. 2023 Oct 25;24:e941440. doi: 10.12659/AJCR.941440.
BACKGROUND Schwannomas are rare and benign tumors of the nerve sheath, composed of Schwann cells, and they are extremely rare in the nasal area. Here, we report a case that presented to our clinic as a growing nasal mass and was found to be a unilateral subcutaneous schwannoma. There have been a few previous cases reported of such patients having nasal obstruction, epistaxis, or other symptoms, but our patient did not. We stress the importance of considering schwannoma in the differential diagnosis of nasal masses, even in pediatric patients, and the role of histopathology differentiating it from other diagnoses such as neurofibroma. CASE REPORT Our patient was a 9-year-old girl with a painless nasal swelling on the nasal bridge that she first noticed 2 years ago, which started growing gradually and began to become firm. She was otherwise asymptomatic and had no relevant family history. Histopathology revealed an encapsulated spindle cell tumor with both hypo- and hyper-cellular areas, and immunohistochemistry showed that the tumor was strongly positive for S-100 and negative for both desmin and CD34, with blood vessels marking. A final diagnosis of schwannoma was made. CONCLUSIONS We presented a case of nasal septal schwannoma, emphasizing the importance of considering schwannoma in the differential diagnosis of nasal masses, and the role of histopathology to rule out other possible diagnoses.
神经鞘瘤是一种罕见的良性神经鞘肿瘤，由施万细胞组成，在鼻腔内极为罕见。在此，我们报告了一例在我院就诊的鼻腔生长性肿块病例，经诊断为单侧皮下神经鞘瘤。既往曾有少数此类患者出现鼻腔阻塞、鼻出血或其他症状的报道，但我们的患者没有。我们强调了在鉴别鼻腔肿块时考虑神经鞘瘤的重要性，即使是在儿科患者中，以及组织病理学在将其与神经纤维瘤等其他诊断区分开来的作用。
我们的患者是一名 9 岁女孩，2 年前发现鼻梁无痛性肿胀，开始逐渐增大且质地变硬。她无其他症状，也没有相关家族史。组织病理学显示为具有细胞稀疏区和细胞密集区的包膜梭形细胞肿瘤，免疫组织化学显示肿瘤 S-100 强阳性，而肌间蛋白和 CD34 均阴性，血管标记阳性。最终诊断为神经鞘瘤。
我们报告了一例鼻中隔神经鞘瘤病例，强调了在鉴别鼻腔肿块时考虑神经鞘瘤的重要性，以及组织病理学在排除其他可能诊断中的作用。
