Watanabe C, Suzuki T
Toxicol Appl Pharmacol. 1986 Dec;86(3):372-9. doi: 10.1016/0041-008x(86)90364-9.
The effect of sodium selenite (SS) on the body temperature of adult male ICR mice was examined. SS (10-60 mumol/kg) administered subcutaneously resulted in a transient and dose-dependent hypothermia at ambient temperatures (Ta) of 20 and 30 degrees C. Reduced oxygen consumption accompanied the changes in body temperature. In addition, SS-treated mice exhibited transient cold-seeking behavior in the thermogradient. This SS-induced hypothermia was very similar to those induced by ethanol, tetrahydrocannabinol, triethyltin, sulfolane, and chlordimeform in that these all were transient, dependent on Ta, and not counteracted by behavioral thermoregulation. From these results, involvement of neural afferent or integral pathways is suggested. Further, acute mortality of SS-injected mice was enhanced with the elevation of Ta, as in the case of the chemicals mentioned above. Considering the diverse chemical and pharmacological properties of these chemicals, these results may suggest a possible interrelation between the hypothermic response and the modification of toxicity.
研究了亚硒酸钠（SS）对成年雄性ICR小鼠体温的影响。皮下注射SS（10 - 60 μmol/kg）在20和30摄氏度的环境温度（Ta）下会导致短暂的剂量依赖性体温过低。体温变化伴随着耗氧量的减少。此外，经SS处理的小鼠在温度梯度中表现出短暂的畏寒行为。这种由SS诱导的体温过低与由乙醇、四氢大麻酚、三乙基锡、环丁砜和杀虫脒诱导的体温过低非常相似，因为这些都是短暂的，依赖于Ta，并且不受行为体温调节的抵消。从这些结果来看，提示了神经传入或整合途径的参与。此外，与上述化学物质的情况一样，随着Ta的升高，注射SS的小鼠的急性死亡率会增加。考虑到这些化学物质多样的化学和药理特性，这些结果可能提示体温过低反应与毒性改变之间可能存在相互关系。
