Gordon C J, Long M D, Dyer R S
Arch Toxicol. 1984 Dec;56(2):123-7. doi: 10.1007/BF00349084.
Sulfolane toxicity may be partially due to its effects on body temperature. To examine the effects of sulfolane on thermoregulation, we measured metabolic rate (oxygen uptake) and body temperature in rats injected intraperitoneally with sulfolane at dosages of 0, 200, 400, and 800 mg/kg. At ambient temperatures (Ta) of 15 and 25 degrees C sulfolane caused a dose-related inhibition of metabolic rate accompanied by hypothermia 60 min post-injection. At a Ta of 35 degrees C, sulfolane had no effect on body temperature or metabolic rate. The hypometabolic and hypothermic effect of sulfolane at a Ta of 25 degrees C at least 2.5 h. Sulfolane had near identical effects on body temperature at TaS of 15 and 25 degrees C, hence, the sulfolane-treated rat had some control over body temperature at a relatively low Ta.
环丁砜毒性可能部分归因于其对体温的影响。为了研究环丁砜对体温调节的影响，我们测量了腹腔注射剂量为0、200、400和800mg/kg环丁砜的大鼠的代谢率（氧气摄取量）和体温。在15℃和25℃的环境温度（Ta）下，环丁砜在注射后60分钟引起剂量相关的代谢率抑制，并伴有体温过低。在35℃的Ta下，环丁砜对体温或代谢率没有影响。在25℃的Ta下，环丁砜的低代谢和低温效应至少持续2.5小时。环丁砜在15℃和25℃的TaS下对体温有几乎相同的影响，因此，经环丁砜处理的大鼠在相对较低的Ta下对体温有一定的控制能力。
