Iida Yoshiyuki, Okada Shinichi, Irifune Yuki, Goto Seiya, Ishida Kotaro, Sato Fuyuki, Yurikusa Takashi, Asakura Koiku, Tsuzuki Ayaka, Mukaigawa Takashi
Division of Head and Neck Surgery, Shizuoka Cancer Center, Sunto-gun, Japan.
Division of Otorhinolaryngology, Iida ENT Clinic, Toride, Japan.
Int Arch Otorhinolaryngol. 2023 Oct 23;27(4):e551-e558. doi: 10.1055/s-0042-1755433. eCollection 2023 Oct.
Oral carcinoma has been reported at a substantial proportion in patients who never smoke and never drink. However, the proportion may vary by subsite and ethnicity. We aimed to determine the clinicopathological features of buccal squamous cell carcinoma (SCC) in a Japanese population. We retrospectively analyzed the records of patients diagnosed with buccal SCC at our institution from September 2002 to November 2015. We reviewed the gender, age, tumor status, treatment, smoking, alcohol drinking, multiple primary cancers, and prognosis of the patients. The overall and cause-specific survival rates were calculated, and the effects of clinicopathological variables were assessed by univariate analysis. Furthermore, the cause of death was evaluated. Among the 63 patients (men: 38; women: 25) included in the present study, 29 (46.0%) never smoked or drank. Women were almost 5 years older than men ( = 0.014). The number of women in the group who never smoked or drank was disproportionately higher than that of those in the smoker or drinker groups ( < 0.001). In total, 29 patients (46.0%) had 59 multiple primary cancers, including 26 oral cancers. Surgeries and radiotherapy were performed in 57 (90.5%) and 6 (9.5%) cases, respectively. The 5-year overall survival and disease-specific survival rates were 74.6 and 78.8%, respectively. Our study confirms that buccal SCC may develop in older adult Japanese patients, especially in women who have never smoked or drank. These patients could be at risk for second primary malignancy.
在从不吸烟和从不饮酒的患者中，口腔癌的报告比例相当高。然而，这一比例可能因亚部位和种族而异。 我们旨在确定日本人群颊部鳞状细胞癌（SCC）的临床病理特征。 我们回顾性分析了2002年9月至2015年11月在我院诊断为颊部SCC的患者记录。我们审查了患者的性别、年龄、肿瘤状况、治疗、吸烟、饮酒、多原发性癌症和预后。计算了总生存率和病因特异性生存率，并通过单因素分析评估了临床病理变量的影响。此外，还评估了死亡原因。 在本研究纳入的63例患者（男性：38例；女性：25例）中，29例（46.0%）从不吸烟或饮酒。女性比男性大近5岁（ = 0.014）。从不吸烟或饮酒组中的女性人数比吸烟者或饮酒者组中的女性人数高得不成比例（ < 0.001）。共有29例患者（46.0%）患有59种多原发性癌症，其中包括26例口腔癌。分别有57例（90.5%）和6例（9.5%）患者接受了手术和放疗。5年总生存率和疾病特异性生存率分别为74.6%和78.8%。 我们的研究证实，颊部SCC可能发生在老年日本患者中，尤其是从不吸烟或饮酒的女性。这些患者可能有发生第二原发性恶性肿瘤的风险。
