Andre K, Schraub S, Mercier M, Bontemps P
Registre des Tumeurs du Doubs, CHU Jean Minjoz, Besancon, France.
Eur J Cancer B Oral Oncol. 1995 Sep;31B(5):301-9. doi: 10.1016/0964-1955(95)00041-0.
A case-control study conducted from 1986 to 1989 using the Doubs Cancer Registry included 299 cases of head and neck cancer and 645 controls from the general population. The results provide an indicator of the respective roles of alcohol and tobacco in all these cancers and on the tumour site. The people who smoked more than one packet of cigarettes a day have a risk that is 13 times higher than that of non-smokers and those who drink more than one and a half litres of wine per day have a risk that is 34 times higher of developing head and neck cancer. The combined exposure of alcohol and tobacco is characterised by a high risk and can be described by a multiplicative model without interaction. The age at onset (below 18 years of age) and the duration of smoking (over 35 years) are high risk factors. The risk decreases after stopping smoking, but only casual smokers (less than 7 cigarettes per day) can hope to have the same risk as non-smokers within a period of 15 years. Subjects smoking only non-filter cigarettes have a higher risk (OR = 1.98) than those who smoke filter cigarettes. The same applies to those who roll their own cigarettes (OR = 1.93) or inhale the smoke (OR = 1.51).
一项于1986年至1989年利用杜省癌症登记处开展的病例对照研究纳入了299例头颈癌病例以及645名来自普通人群的对照。研究结果表明了酒精和烟草在所有这些癌症以及肿瘤部位各自所起的作用。每天吸烟超过一包的人患癌风险比不吸烟者高13倍，而每天饮酒超过1.5升的人患头颈癌的风险比不饮酒者高34倍。酒精和烟草的联合暴露具有高风险特征，并且可以用无交互作用的相乘模型来描述。发病年龄（18岁以下）和吸烟持续时间（超过35年）是高风险因素。戒烟后风险会降低，但只有偶尔吸烟者（每天少于7支烟）有望在15年内将风险降至与不吸烟者相同。只抽非过滤嘴香烟的人比抽过滤嘴香烟的人患癌风险更高（比值比=1.98）。自己卷烟抽的人（比值比=1.93）或吸入烟雾的人（比值比=1.51）也是如此。
