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经鼻中隔瓣上提经蝶入路后嗅觉功能的长期恢复模式

Long-term Recovery Patterns of Olfactory Function after Trans-sphenoidal Approach with Nasoseptal Flap Elevation.

作者信息

Koo Bon Min, Jeong Jong In

机构信息

Department of Otolaryngology, Keimyung University School of Medicine, Dongsan Hospital, Daegu, Republic of Korea.

出版信息

Int Arch Otorhinolaryngol. 2023 Oct 23;27(4):e699-e705. doi: 10.1055/s-0043-1761168. eCollection 2023 Oct.


DOI:10.1055/s-0043-1761168
PMID:37876692
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10593539/
Abstract

Nasoseptal flap is widely used in reconstruction of the skull base to prevent cerebrospinal fluid leakage after surgery for skull base lesions. There has been a debate on whether more severe olfactory dysfunction occurs after nasoseptal flap elevation than the conventional trans-sphenoidal approach.  To compare the long-term recovery patterns associated with nasoseptal flap and the conventional trans-sphenoidal approach.  The subjects were divided into the conventional trans-sphenoidal approach group and the nasoseptal flap elevation group. We followed up self-reported olfactory score using the visual analogue scale and threshold discrimination identification (TDI) score of the Korean Version of the Sniffin Stick test II for 12 months, with olfactory training.  The study included 31 patients who underwent the trans-sphenoidal approach. Compared with preoperative status, the mean visual analogue scale and TDI scores in the conventional trans-sphenoidal approach group recovered 2 months postoperatively, while in the nasoseptal flap elevation group the visual analogue scale and TDI scores recovered 6 months and 3 months after surgery, respectively. Twelve months after surgery, the visual analogue scale and TDI scores in the conventional trans-sphenoidal approach group were 9.3 ± 0.5 and 28.5 ± 4.3, while those from the nasoseptal flap elevation group were 8.9 ± 1.5 and 27.2 ± 4.7 (  = 0.326; 0.473). Only one of the patients in the nasoseptal flap elevation group had permanent olfactory dysfunction.  The olfactory function recovered more gradually in the nasoseptal flap elevation group than in the conventional trans-sphenoidal approach group, but there was no difference between the two groups after 6 months.

摘要

鼻中隔瓣广泛应用于颅底重建,以预防颅底病变手术后的脑脊液漏。关于鼻中隔瓣掀起术后是否比传统经蝶窦入路会出现更严重的嗅觉功能障碍,一直存在争议。 为比较鼻中隔瓣与传统经蝶窦入路相关的长期恢复模式。 将受试者分为传统经蝶窦入路组和鼻中隔瓣掀起组。我们使用视觉模拟量表对自我报告的嗅觉评分进行随访,并采用韩国版嗅觉棒测试II的阈值辨别识别(TDI)评分,进行为期12个月的嗅觉训练。 该研究纳入了31例行经蝶窦入路手术的患者。与术前状态相比,传统经蝶窦入路组的平均视觉模拟量表和TDI评分在术后2个月恢复,而鼻中隔瓣掀起组的视觉模拟量表和TDI评分分别在术后6个月和3个月恢复。术后12个月,传统经蝶窦入路组的视觉模拟量表和TDI评分分别为9.3±0.5和28.5±4.3,而鼻中隔瓣掀起组的分别为8.9±1.5和27.2±4.7(P = 0.326;0.473)。鼻中隔瓣掀起组中只有1例患者存在永久性嗅觉功能障碍。 鼻中隔瓣掀起组的嗅觉功能恢复比传统经蝶窦入路组更缓慢,但6个月后两组之间无差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a20a/10593539/1e89f4fcbde5/10-1055-s-0043-1761168-i221290-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a20a/10593539/0d4196cf47fe/10-1055-s-0043-1761168-i221290-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a20a/10593539/1e89f4fcbde5/10-1055-s-0043-1761168-i221290-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a20a/10593539/0d4196cf47fe/10-1055-s-0043-1761168-i221290-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a20a/10593539/1e89f4fcbde5/10-1055-s-0043-1761168-i221290-2.jpg

相似文献

[1]
Long-term Recovery Patterns of Olfactory Function after Trans-sphenoidal Approach with Nasoseptal Flap Elevation.

Int Arch Otorhinolaryngol. 2023-10-23

[2]
Bilateral nasoseptal flaps for endoscopic endonasal transsphenoidal approach.

J Craniofac Surg. 2013-9

[3]
Analysis of Olfaction after Bilateral Nasoseptal Rescue Flap Transsphenoidal Approach with Olfactory Mucosal Preservation.

Otolaryngol Head Neck Surg. 2019-7-23

[4]
Bilateral modified nasoseptal "rescue" flaps in the endoscopic endonasal transsphenoidal approach.

Laryngoscope. 2013-4-1

[5]
Olfactory bulb volume changes associated with trans-sphenoidal pituitary surgery.

PLoS One. 2019-12-18

[6]
Impact of nasoseptal flap elevation on sinonasal quality of life in endoscopic endonasal approach to pituitary adenomas.

Eur Arch Otorhinolaryngol. 2016-5

[7]
Olfactory changes after endoscopic endonasal transsphenoidal approach for skull base tumors.

Laryngoscope. 2014-11

[8]
Complications associated with the pedicled nasoseptal flap for skull base reconstruction.

Laryngoscope. 2015-1

[9]
Relaxing Sphenoidal Slit Incision to Extend the Anterior and Posterior Reach of Pedicled Nasoseptal Flaps During Endoscopic Skull Base Reconstruction of Transcribriform Defects: Technical Note and Results in 20 Patients.

World Neurosurg. 2018-5

[10]
Sinonasal outcomes following endoscopic anterior skull base surgery with nasoseptal flap reconstruction: a prospective study.

J Laryngol Otol. 2015-7

本文引用的文献

[1]
Evaluation of olfactory function in patients undergoing endoscopic skull base surgery with nasoseptal flap.

Braz J Otorhinolaryngol. 2022

[2]
Olfactory function in patients after transsphenoidal surgery for pituitary adenomas-a short review.

Neurosurg Rev. 2019-6

[3]
Impact of nasoseptal flap elevation on sinonasal quality of life in endoscopic endonasal approach to pituitary adenomas.

Eur Arch Otorhinolaryngol. 2016-5

[4]
Complications associated with the pedicled nasoseptal flap for skull base reconstruction.

Laryngoscope. 2015-1

[5]
A panoramic view of the skull base: systematic review of open and endoscopic endonasal approaches to four tumors.

Pituitary. 2014-8

[6]
Impairment of olfaction and mucociliary clearance after expanded endonasal approach using vascularized septal flap reconstruction for skull base tumors.

Neurosurgery. 2013-4

[7]
Olfactory outcomes following endoscopic pituitary surgery with or without septal flap reconstruction: a randomized controlled trial.

Int Forum Allergy Rhinol. 2012-8-2

[8]
The expanding role of endoscopic skull base surgery.

Br J Neurosurg. 2012-10

[9]
Olfactory outcomes after endoscopic transsphenoidal pituitary surgery.

Laryngoscope. 2011-6-6

[10]
Nasoseptal "rescue" flap: a novel modification of the nasoseptal flap technique for pituitary surgery.

Laryngoscope. 2011-5

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