复发性呼吸道乳头瘤病在免疫抑制人群中的疾病进程。
Recurrent respiratory papillomatosis disease course in immunosuppressed populations.
机构信息
Ohio State University College of Medicine, Columbus, OH, USA.
Ohio State University Wexner Medical Center, Columbus, OH, USA.
出版信息
J Laryngol Otol. 2024 May;138(5):576-580. doi: 10.1017/S0022215123001470. Epub 2023 Oct 25.
OBJECTIVE
Recurrent respiratory papillomatosis is a benign manifestation of human papillomavirus types 6 and 11 in the respiratory tract. Disease is recurrent, and factors predicting these recurrences and severity of disease are incompletely characterised. This retrospective cohort study examined the relationship of immunosuppression with recurrent respiratory papillomatosis morbidity.
METHODS
A retrospective cohort of 97 adult patients with recurrent respiratory papillomatosis treated at a tertiary referral centre from 2005 to 2020 was conducted. Measures assessed included inter-surgical interval, Voice Handicap Index ('VHI-10') and anatomical Derkay scores.
RESULTS
Bivariate analyses comparing average inter-surgical interval, Voice Handicap Index and Derkay scores in immunosuppressed and healthy patients were insignificant. When controlling for diabetes mellitus and comparing immunosuppressed to healthy patients, inter-surgical interval and Voice Handicap Index change were insignificant ( = 0.458 and = 0.465, respectively).
CONCLUSION
Recurrent respiratory papillomatosis morbidity for immunosuppressed patients did not significantly differ from that of immunocompetent patients.
目的
复发性呼吸道乳头瘤病是人类乳头瘤病毒 6 型和 11 型在呼吸道的良性表现。疾病具有复发性，预测这些复发和疾病严重程度的因素尚未完全确定。本回顾性队列研究探讨了免疫抑制与复发性呼吸道乳头瘤病发病率的关系。
方法
对 2005 年至 2020 年在一家三级转诊中心接受治疗的 97 例复发性呼吸道乳头瘤病成年患者进行了回顾性队列研究。评估的措施包括手术间隔时间、嗓音障碍指数（VHI-10）和解剖学德凯评分。
结果
对免疫抑制患者和健康患者的平均手术间隔时间、嗓音障碍指数和德凯评分进行双变量分析，差异无统计学意义。当控制糖尿病并比较免疫抑制患者与健康患者时，手术间隔时间和嗓音障碍指数的变化差异无统计学意义（=0.458 和=0.465）。
结论
免疫抑制患者的复发性呼吸道乳头瘤病发病率与免疫功能正常患者无显著差异。
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