Department of Medical Physics, Osaka Heavy Ion Therapy Center, Osaka, Japan.
Department of Carbon Ion Radiotherapy, Osaka University Graduate School of Medicine, Osaka, Japan.
Med Phys. 2024 Mar;51(3):2239-2250. doi: 10.1002/mp.16791. Epub 2023 Oct 25.
Using the pencil beam raster scanning method employed at most carbon beam treatment facilities, spots can be moved without interrupting the beam, allowing for the delivery of a dose between spots (move dose). This technique is also known as Dose-Driven-Continuous-Scanning (DDCS). To minimize its impact on HIMAK patient dosimetry, there's an upper limit to the move dose. Spots within a layer are grouped into sets, or "break points," allowing continuous irradiation. The beam is turned off when transitioning between sets or at the end of a treatment layer or spill. The control system beam-off is accomplished by turning off the RF Knockout (RFKO) extraction and after a brief delay the High Speed Steering Magnet (HSST) redirects the beam transport away from isocenter to a beam dump.
The influence of the move dose and beam on/off control on the dose distribution and irradiation time was evaluated by measurements never before reported and modelled for Hitachi Carbon DDCS.
We conducted fixed-point and scanning irradiation experiments at three different energies, both with and without breakpoints. For fixed-point irradiation, we utilized a 2D array detector and an oscilloscope to measure beam intensity over time. The oscilloscope data enabled us to confirm beam-off and beam-on timing due to breakpoints, as well as the relative timing of the RFKO signal, HSST signal, and dose monitor (DM) signals. From these measurements, we analyzed and modelled the temporal characteristics of the beam intensity. We also developed a model for the spot shape and amplitude at isocenter occurring after the beam-off signal which we called flap dose and its dependence on beam intensity. In the case of scanning irradiation, we measured move doses using the 2D array detector and compared these measurements with our model.
We observed that the most dominant time variation of the beam intensity was at 1 kHz and its harmonic frequencies. Our findings revealed that the derived beam intensity cannot reach the preset beam intensity when each spot belongs to different breakpoints. The beam-off time due to breakpoints was approximately 100 ms, while the beam rise time and fall time (t ) were remarkably fast, about 10 ms and 0.2 ms, respectively. Moreover, we measured the time lag (t ) of approximately 0.2 ms between the RFKO and HSST signals. Since t ≈ t at HIMAK then the HSST is activated after the residual beam intensity, resulting in essentially zero flap dose at isocenter from the HSST. Our measurements of the move dose demonstrated excellent agreement with the modelled move dose.
We conducted the first move dose measurement for a Hitachi Carbon synchrotron, and our findings, considering beam on/off control details, indicate that Hitachi's carbon synchrotron provides a stable beam at HIMAK. Our work suggests that measuring both move dose and flap dose should be part of the commissioning process and possibly using our model in the Treatment Planning System (TPS) for new facilities with treatment delivery control systems with higher beam intensities and faster beam-off control.
在大多数碳束治疗设施中采用铅笔束光栅扫描方法,可以在不中断光束的情况下移动光斑,从而在光斑之间输送剂量(移动剂量)。这种技术也称为剂量驱动连续扫描(DDCS)。为了将其对 HIMAK 患者剂量学的影响降至最低,移动剂量有一个上限。层内的光斑被分组为“断点”,以实现连续照射。在组之间切换时、在治疗层结束时或溢出时,会关闭光束。通过关闭射频敲出(RFKO)提取来实现控制系统光束关闭,并且在短暂延迟之后,高速转向磁铁(HSST)将束流从等中心重新引导到束流dump。
通过以前从未报告过的测量和为日立碳 DDCS 建模,评估移动剂量和束流开/关控制对剂量分布和照射时间的影响。
我们在三个不同的能量下进行了定点和扫描照射实验,既有断点也有无断点。对于定点照射,我们使用二维阵列探测器和示波器来测量随时间变化的束流强度。示波器数据使我们能够确认由于断点导致的束流关闭和开启时间,以及 RFKO 信号、HSST 信号和剂量监测器(DM)信号的相对定时。根据这些测量,我们分析和建模了束流强度的时间特性。我们还开发了一个模型,用于描述在束流关闭信号后等中心处出现的光斑形状和幅度,我们称之为瓣状剂量及其对束流强度的依赖性。在扫描照射的情况下,我们使用二维阵列探测器测量移动剂量,并将这些测量结果与我们的模型进行比较。
我们观察到,束流强度的最主要的时间变化是在 1 kHz 及其谐波频率。我们的发现表明,当每个光斑属于不同的断点时,导出的束流强度无法达到预设的束流强度。由于断点导致的束流关闭时间约为 100ms,而束流上升时间和下降时间(t)非常快,约为 10ms 和 0.2ms。此外,我们测量了 RFKO 和 HSST 信号之间的时间滞后(t)约为 0.2ms。由于 t≈t 在 HIMAK 中,因此 HSST 是在残余束流强度之后激活的,导致在等中心处实质上没有来自 HSST 的瓣状剂量。我们对移动剂量的测量与建模的移动剂量非常吻合。
我们对日立碳同步加速器进行了首次移动剂量测量,考虑到束流开/关控制细节,我们的研究结果表明,日立的碳同步加速器在 HIMAK 中提供了稳定的束流。我们的工作表明,在新设施的调试过程中,应该同时测量移动剂量和瓣状剂量,并可能在具有更高束流强度和更快束流关闭控制的治疗输送控制系统的治疗计划系统(TPS)中使用我们的模型。