Department of Radiation Oncology, Mayo Clinic Florida, Jacksonville, FL32224, United States of America.
Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, HA450052, People's Republic of China.
Phys Med Biol. 2022 Aug 17;67(17). doi: 10.1088/1361-6560/ac8410.
To investigate synchrotron-based proton pencil beam scanning (PBS) beam delivery time (BDT) using novel continuous scanning mode.A BDT calculation model was developed for the Hitachi particle therapy system. The model was validated against the measured BDT of 36 representative clinical proton PBS plans with discrete spot scanning (DSS) in the current Hitachi proton therapy system. BDTs were calculated with the next generation using Mayo Clinic Florida system operating parameters for conventional DSS, and novel dose driven continuous scanning (DDCS). BDTs of DDCS with and without Break Spots were investigated.For DDCS without Break Spots, the use of Stop Ratio to control the transit dose largely reduced the beam intensity and consequently, severely prolonged the BDT. DDCS with Break Spots was able to maintain a sufficiently high beam intensity while controlling transit dose. In DDCS with Break Spots, tradeoffs were made between beam intensity and number of Break Spots. Therefore, BDT decreased with increased beam intensity but reached a plateau for beam intensity larger than 10 MU s. Averaging over all clinical plans, BDT was reduced by 10% for DDCS with Break Spots compared to DSS.DDCS with Break Spots reduced BDT. DDCS has the potential to further reduce BDT under the ideal scenario which requests both stable beam intensity extraction and accurately modelling the transit dose. Further investigation is warranted.
利用新型连续扫描模式研究基于同步加速器的质子铅笔束扫描(PBS)束传输时间(BDT)。为日立粒子治疗系统开发了 BDT 计算模型。该模型通过当前日立质子治疗系统中离散点扫描(DSS)的 36 个代表性临床质子 PBS 计划的测量 BDT 进行了验证。使用佛罗里达梅奥诊所系统的下一代操作参数计算了常规 DSS 和新型剂量驱动连续扫描(DDCS)的 BDT。研究了带和不带间断点的 DDCS 的 BDT。对于不带间断点的 DDCS,使用停止比来控制传输剂量会大大降低束强度,从而严重延长 BDT。带有间断点的 DDCS 能够在控制传输剂量的同时保持足够高的束强度。在带有间断点的 DDCS 中,在束强度和间断点数量之间进行了权衡。因此,随着束强度的增加,BDT 会降低,但当束强度大于 10MU s 时,BDT 会达到一个平台。平均所有临床计划,带间断点的 DDCS 与 DSS 相比,BDT 降低了 10%。带有间断点的 DDCS 缩短了 BDT。在需要稳定的束强度提取和准确建模传输剂量的理想情况下,DDCS 有可能进一步缩短 BDT。需要进一步研究。