Emerg Infect Dis. 2023 Nov;29(11):2395-2397. doi: 10.3201/eid2911.230499.
Salmonella Typhi infection in a patient in Pakistan initially responded to standard treatment but failed to respond to subsequent treatment. The first strain was susceptible to carbapenems and azithromycin; subsequent strains harbored the NDM-5 gene. Treatment with a combination of intravenous meropenem and colistin was successful. Carbapenem-resistant Salmonella Typhi emergence will hinder treatment.
巴基斯坦一名患者的伤寒沙门氏菌感染最初对标准治疗有反应,但随后的治疗无效。第一株菌对碳青霉烯类和阿奇霉素敏感;随后的菌株携带 NDM-5 基因。联合使用静脉注射美罗培南和黏菌素治疗成功。碳青霉烯类耐药伤寒沙门氏菌的出现将阻碍治疗。