Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, California, USA.
Department of Biological Chemistry, University of California Irvine, Irvine, California, USA.
mBio. 2023 Dec 19;14(6):e0230823. doi: 10.1128/mbio.02308-23. Epub 2023 Oct 25.
The gut microbiome serves as an interface between the host and the diet. Diet and the gut microbiome both play important roles in managing inflammation, which is a key aspect of myeloproliferative neoplasm (MPN). Studies have shown that a Mediterranean (MED) diet can reduce inflammation. Therefore, we longitudinally characterized the gut microbiomes of MPN patients in response to Mediterranean or standard 2020 US Guidelines for Americans dietary counseling to determine whether there were microbiome-associated changes in inflammation. We did not find significant changes in the gut microbiome associated with diet, but we did find several associations with inflammation. This research paves the way for future studies by identifying potential mechanistic targets implicated in inflammation within the MPN gut microbiome.
肠道微生物组作为宿主和饮食之间的接口。饮食和肠道微生物组在管理炎症方面都起着重要作用，而炎症是骨髓增生性肿瘤（MPN）的一个关键方面。研究表明，地中海饮食（MED）可以减少炎症。因此，我们对 MPN 患者的肠道微生物组进行了纵向特征分析，以响应地中海饮食或 2020 年美国标准美国人饮食咨询指南，以确定炎症是否与微生物组相关的变化。我们没有发现与饮食相关的肠道微生物组的显著变化，但我们确实发现了一些与炎症相关的变化。这项研究通过确定 MPN 肠道微生物组中与炎症相关的潜在机制靶点，为未来的研究铺平了道路。
