Technofunctional Starters Lab, National Collection of Dairy Cultures, Dairy Microbiology Division, ICAR-National Dairy Research Institute, Karnal 132001, Haryana, India.
Proteomics and Cell Biology Lab, Animal Biotechnology Center, National Dairy Research Institute, Karnal 132001, Haryana, India.
Food Res Int. 2021 Dec;150(Pt A):110716. doi: 10.1016/j.foodres.2021.110716. Epub 2021 Sep 30.
Emerging evidence and an in-depth understanding of the microbiome have helped in identifying beneficial commensals and their therapeutic potentials. Specific commensal taxa/ strains of the human gut microbiome have been positively associated with human health and recently termed as next-generation probiotics (NGPs). Of these, Akkermansia muciniphila, Ruminococcus bromii, Faecalibacterium prausnitzii, Anaerobutyricum hallii, and Roseburia intestinalis are the five most relevant gut-derived NGPs that have demonstrated therapeutic potential in managing metabolic diseases. Specific and natural dietary interventions can modulate the abundance and activity of these beneficial bacteria in the gut. Hence, the understanding of targeted stimulation of specific NGP by specific probiotic-targeted diets (PTD) is indispensable for the rational application of their combination. The supplementation of NGP with its specific PTD will help the strain(s) to compete with harmful microbes and acquire its niche. This combination would enhance the effectiveness of NGPs to be used as "live biotherapeutic products" or food nutraceuticals. Under the current milieu, we review various PTDs that influence the abundance of specific potential NGPs, and contemplates potential interactions between diet, microbes, and their effects on host health. Taking into account the study mentioned, we propose that combining NGPs will provide an alternate solution for developing the new diet in conjunction with PTD.
新兴的证据和对微生物组的深入了解有助于识别有益的共生体及其治疗潜力。人类肠道微生物组的特定共生体分类群/菌株与人类健康呈正相关，最近被称为下一代益生菌（NGP）。其中，阿克曼氏菌、布氏瘤胃球菌、普拉梭菌、丁酸梭菌和罗斯伯里氏菌是与代谢疾病管理的治疗潜力相关的 5 种最相关的肠道衍生 NGPs。特定的天然饮食干预可以调节这些有益细菌在肠道中的丰度和活性。因此，了解特定益生菌靶向饮食（PTD）对特定 NGP 的靶向刺激是合理应用其组合所必需的。用其特定的 PTD 补充 NGP 将有助于菌株与有害微生物竞争并获得其生态位。这种组合将提高 NGPs 作为“活体生物治疗产品”或食品营养保健品的有效性。在当前环境下，我们回顾了影响特定潜在 NGPs 丰度的各种 PTD，并考虑了饮食、微生物及其对宿主健康影响之间的潜在相互作用。考虑到所提到的研究，我们提出将 NGPs 联合起来将为开发与 PTD 相结合的新饮食提供替代解决方案。
