Ugarte-Carbajal Valeria, Vela-Ruiz José M, Guillen-Ponce Vela-Rui, Correa-López Lucy E, Rubin-de-Celis Verónica, Cruz-Vargas Jhony A De La
Instituto de Investigaciones en Ciencias Biomédicas, Universidad Ricardo Palma, Lima-Peru.
Instituto de Investigaciones en Ciencias Biomédicas, Universidad Ricardo Palma, Lima-Peru;Lifestyle Medicine Department, Universidad Ricardo Palma, Lima-Peru.
Urol Res Pract. 2023 Jan;49(1):19-24. doi: 10.5152/tud.2023.22236.
This study aimed to determine how metabolic syndrome is related to benign prostatic enlargement in males under 60 years old in a national military hospital in Peru.
We conducted a retrospective, quantitative, case-control study. By simple random sampling, 87 cases with benign prostatic enlargement and 174 controls were included, with a statistical power of 80%. The benign prostatic enlargement was evaluated by clinical picture and ultrasound and the metabolic syndrome was evaluated according to the Adult Treatment Panel III criteria. The statistical analysis was performed using the STATAv14 program, the chi-square statistical test was used and odds ratio was obtained, at a significance level of 5%.
The mean age of the cases and controls was 55 (51-58) and 52 (46-57), respectively. By multivariate analysis, the factors related to benign prostatic enlargement were the presence of benign prostatic enlargement (adjusted odds ratio: 2.71, 95% CI: 1.27-5.80; P=.010), waist circumference ≥102 cm (adjusted odds ratio: 6.51, 95% CI: 3.09-13.71; P < .001), elevated fasting glucose (adjusted odds ratio: 1.38, 95% CI: 0.65-2.91; P=.399), high triglycerides (adjusted odds ratio: 5.29, 95%: CI 2.40-11.64; P < .001), and arterial hypertension (adjusted odds ratio: 4.67, 95% CI 2.19-9.95; P < .001). Elevated high-density lipoprotein cholesterol was a protective factor (adjusted odds ratio: 0.09, 95% CI: 0.04-0.20; P < .001).
The present study showed that metabolic syndrome and its components (waist circumference, hypertension, triglycerides, and high-density lipoprotein cholesterol) are factors related to benign prostatic enlargement in patients under 60 years old in a military hospital in Peruvian population. Waist circumference as an indicator of overweight/obesity is a practical anthropometric marker of interest in public health.
本研究旨在确定在秘鲁一家国立军事医院中，60岁以下男性的代谢综合征与良性前列腺增生之间的关系。
我们开展了一项回顾性、定量、病例对照研究。通过简单随机抽样，纳入了87例良性前列腺增生患者和174例对照，统计效能为80%。通过临床表现和超声评估良性前列腺增生，根据成人治疗小组III标准评估代谢综合征。使用STATAv14程序进行统计分析，采用卡方统计检验并获得比值比，显著性水平为5%。
病例组和对照组的平均年龄分别为55岁（51 - 58岁）和52岁（46 - 57岁）。多因素分析显示，与良性前列腺增生相关的因素包括良性前列腺增生的存在（调整后比值比：2.71，95%可信区间：1.27 - 5.80；P = 0.010）、腰围≥102 cm（调整后比值比：6.51，95%可信区间：3.09 - 13.71；P < 0.001）、空腹血糖升高（调整后比值比：1.38，95%可信区间：0.65 - 2.91；P = 0.399）、高甘油三酯（调整后比值比：5.29，95%可信区间：2.40 - 11.64；P < 0.001）以及动脉高血压（调整后比值比：4.67，95%可信区间：2.19 - 9.95；P < 0.001）。高密度脂蛋白胆固醇升高是一个保护因素（调整后比值比：0.09，95%可信区间：0.04 - 0.20；P < 0.001）。
本研究表明，代谢综合征及其组成部分（腰围、高血压、甘油三酯和高密度脂蛋白胆固醇）是秘鲁人群中一家军事医院60岁以下患者良性前列腺增生的相关因素。腰围作为超重/肥胖的指标，是公共卫生领域一个值得关注的实用人体测量标志物。
