Department of Urology, Xianyang Central Hospital, Xianyang, China.
Clinical Research Center of Xianyang City, Xianyang Central Hospital, Xianyang, China.
Am J Mens Health. 2021 Jul-Aug;15(4):15579883211036786. doi: 10.1177/15579883211036786.
The objective of this study is to provide comprehensive and up-to-date estimates on the disease burden of BPH in 204 countries and territories between 1990 and 2019. Data about incidence, year lived with disability (YLD), and their age-standardized rates (ASRs) for 21 regions, 5 Socio-demographic Index (SDI) quintiles, 204 countries and territories, and 12 age categories from 1990 to 2019 were obtained from the Global Burden of Disease 2019 study. Estimated annual percentage changes (EAPCs) of the ASRs and the associations between SDI and the ASRs were estimated. The effects of population growth, population aging, and age-specific rate on the changes in the absolute numbers of incidence and YLD were quantified. Globally, there were 11.26 million (95% uncertainty interval [UI]: 8.79, 14.46) new cases and 1.86 million (95%UI: 1.13, 2.78) YLD due to BPH in 2019. The global ASRs of incidence (EAPC: -0.031, 95% CI: -0.050, -0.012) and YLD (EAPC: -0.058, 95% CI: -0.084, -0.031) decreased slightly from 1990 to 2019, whereas the absolute numbers increased dramatically from 1990 (incidence by 105.7% and YLD by 110.6%), mainly driven by the population growth (53.5% for incidence and 54.4% for YLD) and population aging (55.7% for incidence and 63.2% for YLD). The burden of BPH varied markedly among different regions, socioeconomic status, and countries. As the population is growing and aging, great efforts are required to develop effective prevention, treatment and management strategies to meet the high and increasing burden of BPH worldwide.
本研究旨在提供 1990 年至 2019 年期间 204 个国家和地区 BPH 疾病负担的综合且最新估计值。关于发病率、残疾年数（YLD）及其在 21 个地区、5 个社会人口指数（SDI）五分位数、204 个国家和地区以及 12 个年龄组的年龄标准化率（ASR）的数据，来自 2019 年全球疾病负担研究。估计了 ASR 的年估计百分比变化（EAPC）以及 SDI 与 ASR 之间的关联。量化了人口增长、人口老龄化和特定年龄组对发病率和 YLD 绝对数量变化的影响。全球范围内，2019 年有 1126 万（95%置信区间 [95%CI]：879 万，1446 万）新病例和 186 万（95%CI：113 万，278 万）与 BPH 相关的 YLD。1990 年至 2019 年，发病率（EAPC：-0.031，95%CI：-0.050，-0.012）和 YLD（EAPC：-0.058，95%CI：-0.084，-0.031）的全球 ASR 略有下降，而绝对值却从 1990 年开始大幅增加（发病率增加 105.7%，YLD 增加 110.6%），这主要是由人口增长（发病率 53.5%，YLD 54.4%）和人口老龄化（发病率 55.7%，YLD 63.2%）驱动的。BPH 的负担在不同地区、社会经济地位和国家之间差异显著。随着人口的增长和老龄化，需要做出巨大努力来制定有效的预防、治疗和管理策略，以应对全球范围内 BPH 负担的增加。
