低剂量丙酰氧肟酸（PHA）治疗感染性肾结石的临床经验

Clinical experience with low dosage of propionohydroxamic acid (PHA) in infected renal stones.

作者信息

Martelli A, Buli P, Spatafora S

出版信息

Urology. 1986 Nov;28(5):373-5. doi: 10.1016/0090-4295(86)90064-6.

Abstract

The use of drugs inhibiting bacterial urease represents an interesting improvement in preventive treatment of renal infected stones. The low dose (120 mg/day) for one week followed by 60 mg/day of propionohydroxamic acid (PHA) has shown excellent anti-urease activity. The nearly normal absence of side effects also allows long-term administration.

摘要

使用抑制细菌脲酶的药物是肾感染性结石预防性治疗的一项有趣进展。低剂量（120毫克/天）服用一周，随后60毫克/天的丙酰氧肟酸（PHA）已显示出优异的抗脲酶活性。几乎没有副作用这一情况也使得能够长期给药。