Van de Perre Els, Reichman Gina, De Geyter Deborah, Geers Caroline, Wissing Karl M, Letavernier Emmanuel
Nephrology Department, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
Urology Department, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
Front Med (Lausanne). 2021 Jan 21;7:609024. doi: 10.3389/fmed.2020.609024. eCollection 2020.
Encrusted uropathy is a rare subacute to chronic inflammatory disorder caused by infection with urease-producing bacteria, mainly . The disorder is characterized by urothelial deposition of struvite and carbonated apatite, resulting in encrustations and ulceronecrotic inflammation of the urothelium and surrounding tissues. Most commonly, encrusted uropathy is encountered in patients with predisposing conditions. The disease remains underdiagnosed. High urinary pH and negative conventional urine cultures should raise suspicion of the diagnosis. Prognosis is dependent on timely diagnosis and treatment installment, which consists of urological removal of encrustations in combination with urinary acidification and long-term antibiotic therapy.
结痂性尿路病是一种罕见的亚急性至慢性炎症性疾病，主要由产脲酶细菌感染引起。该疾病的特征是鸟粪石和碳酸磷灰石在尿路上皮沉积，导致尿路上皮和周围组织出现结痂和溃疡坏死性炎症。最常见的情况是，结痂性尿路病在有易感因素的患者中出现。该疾病仍未得到充分诊断。高尿pH值和传统尿培养阴性应引起对该诊断的怀疑。预后取决于及时的诊断和治疗，治疗包括通过泌尿外科手术清除结痂，同时进行尿液酸化和长期抗生素治疗。
