从一株中国来源的 Alg 群弧菌中分离的整合子-转座子元件携带的新型 VIM 型金属β-内酰胺酶 VIM-71 的特性研究。
Characterization of VIM-71, a novel VIM-type metallo-β-lactamase variant encoded by an integrative and conjugative element recovered from a Vibrio alginolyticus strain in China.
机构信息
The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, PR China; State Key Lab for Chemical Biology and Drug Discovery, and the Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
College of Life Sciences, Anhui Normal University, Wuhu, PR China; State Key Lab for Chemical Biology and Drug Discovery, and the Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
出版信息
Microbiol Res. 2024 Jan;278:127532. doi: 10.1016/j.micres.2023.127532. Epub 2023 Oct 19.
A novel VIM-type metallo-β-lactamase variant, VIM-71, which is encoded by a multidrug-resistant Vibrio alginolyticus strain recovered from a shrimp sample in China, was identified. Compared to VIM-1, VIM-71 differs in 22 amino acid positions based on the primary protein sequence and confers a similar resistance profile to penicillins, but the level of resistance to carbapenems encoded by this enzyme was lower than that of VIM-1. The bla gene was found located in an integrative and conjugative element of the SXT/R391 family in the chromosome. These findings implied that genetic elements that encode clinically important carbapenemases continue to evolve in Vibrio spp.
从中国的虾样本中分离出一株耐多药的 Alg 溶藻弧菌，鉴定出一种新型 VIM 型金属β-内酰胺酶变体 VIM-71。与 VIM-1 相比，VIM-71 在一级蛋白序列上有 22 个氨基酸位置不同，对青霉素的耐药谱相似，但该酶编码的碳青霉烯类药物的耐药水平低于 VIM-1。bla 基因位于染色体 SXT/R391 家族的整合和可转移元件中。这些发现表明，编码临床重要碳青霉烯酶的遗传元件在弧菌属中仍在不断进化。
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