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基因工程细胞膜纳米囊泡用于癌症免疫治疗。

Genetically Engineered-Cell-Membrane Nanovesicles for Cancer Immunotherapy.

机构信息

Jinhua Municipal Central Hospital, Jinhua, 321000, China.

Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072, China.

出版信息

Adv Sci (Weinh). 2023 Sep;10(26):e2302131. doi: 10.1002/advs.202302131. Epub 2023 Jul 6.

DOI:10.1002/advs.202302131
PMID:37409429
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10502869/
Abstract

The advent of immunotherapy has marked a new era in cancer treatment, offering significant clinical benefits. Cell membrane as drug delivery materials has played a crucial role in enhancing cancer therapy because of their inherent biocompatibility and negligible immunogenicity. Different cell membranes are prepared into cell membrane nanovesicles (CMNs), but CMNs have limitations such as inefficient targeting ability, low efficacy, and unpredictable side effects. Genetic engineering has deepened the critical role of CMNs in cancer immunotherapy, enabling genetically engineered-CMN (GCMN)-based therapeutics. To date, CMNs that are surface modified by various functional proteins have been developed through genetic engineering. Herein, a brief overview of surface engineering strategies for CMNs and the features of various membrane sources is discussed, followed by a description of GCMN preparation methods. The application of GCMNs in cancer immunotherapy directed at different immune targets is addressed as are the challenges and prospects of GCMNs in clinical translation.

摘要

免疫疗法的出现标志着癌症治疗的新时代，带来了显著的临床获益。细胞膜作为药物递送材料，由于其固有生物相容性和可忽略不计的免疫原性，在增强癌症治疗方面发挥了关键作用。不同的细胞膜被制备成细胞膜纳米囊泡（CMNs），但 CMNs 存在靶向能力不足、疗效低和不可预测的副作用等局限性。基因工程加深了 CMNs 在癌症免疫治疗中的关键作用，使基于基因工程化-CMN（GCMN）的治疗成为可能。迄今为止，通过基因工程已经开发出了各种功能蛋白表面修饰的 CMNs。本文简要概述了 CMNs 的表面工程策略和各种膜源的特点，描述了 GCMN 的制备方法。探讨了 GCMN 在针对不同免疫靶点的癌症免疫治疗中的应用，以及 GCMN 在临床转化中的挑战和前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d236/10502869/349eacad65a0/ADVS-10-2302131-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d236/10502869/349eacad65a0/ADVS-10-2302131-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d236/10502869/57e5afa6d045/ADVS-10-2302131-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d236/10502869/20a5ba497cce/ADVS-10-2302131-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d236/10502869/be7737b9d786/ADVS-10-2302131-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d236/10502869/059b991e6847/ADVS-10-2302131-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d236/10502869/a80da1f535d0/ADVS-10-2302131-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d236/10502869/84d4543576a1/ADVS-10-2302131-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d236/10502869/66fe83be3f23/ADVS-10-2302131-g021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d236/10502869/f2c600e3988b/ADVS-10-2302131-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d236/10502869/0d9e1b879620/ADVS-10-2302131-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d236/10502869/2fb60fc6c3d8/ADVS-10-2302131-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d236/10502869/92c5c099344c/ADVS-10-2302131-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d236/10502869/13625b6eddb2/ADVS-10-2302131-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d236/10502869/f98c16073e95/ADVS-10-2302131-g023.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d236/10502869/8ae6d29a26c9/ADVS-10-2302131-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d236/10502869/1a76248b77a5/ADVS-10-2302131-g008.jpg
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