Guangdong Provincial Key Laboratory of Nanophotonic Manipulation, Institute of Nanophotonics, Jinan University, Guangzhou, 511443, China.
College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China.
Small Methods. 2024 Jan;8(1):e2301112. doi: 10.1002/smtd.202301112. Epub 2023 Oct 25.
The active delivery of nanodrugs has been a bottleneck problem in nanomedicine. While modification of nanodrugs with targeting agents can enhance their retention at the lesion location, the transportation of nanodrugs in the circulation system is still a passive process. The navigation of nanodrugs with external forces such as magnetic field has been shown to be effective for active delivery, but the existing techniques are limited to specific materials like magnetic nanoparticles. In this study, an alternative actuation method is proposed based on optical manipulation for remote navigation of nanodrugs in vivo, which is compatible with most of the common drug carriers and exhibits significantly higher manipulation precision. By the programmable scanning of the laser beam, the motion trajectory and velocity of the nanodrugs can be precisely controlled in real time, making it possible for intelligent drug delivery, such as inverse-flow transportation, selective entry into specific vascular branch, and dynamic circumvention across obstacles. In addition, the controlled mass delivery of nanodrugs can be realized through indirect actuation by the microflow field. The developed optical manipulation method provides a new solution for the active delivery of nanodrugs, with promising potential for the treatment of blood diseases such as leukemia and thrombosis.
纳米药物的主动递药一直是纳米医学的一个瓶颈问题。虽然通过靶向剂对纳米药物进行修饰可以增强它们在病变部位的滞留，但纳米药物在循环系统中的运输仍然是一个被动的过程。利用磁场等外力引导纳米药物的导航已被证明对主动递药是有效的，但现有的技术仅限于特定的材料，如磁性纳米颗粒。在这项研究中，提出了一种基于光学操纵的替代驱动方法，用于在体内远程导航纳米药物，该方法与大多数常见的药物载体兼容，并表现出显著更高的操纵精度。通过激光束的可编程扫描，可以实时精确控制纳米药物的运动轨迹和速度，从而实现智能药物输送，如反向运输、选择性进入特定血管分支以及动态跨越障碍物。此外，通过微流场的间接驱动，可以实现纳米药物的受控质量输送。所开发的光学操纵方法为纳米药物的主动递药提供了一种新的解决方案，有望用于治疗白血病和血栓等血液疾病。
