Cárdenas-Aguazaco William, Lara-Bertrand Adriana Lorena, Prieto-Abello Leonardo, Barreto-López Nicolás, Camacho Bernardo, Silva-Cote Ingrid
Unidad de Ingeniería Tisular, Instituto Distrital de Ciencia, Biotecnología e Innovación en Salud-IDCBIS, Colombia.
Regen Ther. 2024 Jun 1;26:145-160. doi: 10.1016/j.reth.2024.05.017. eCollection 2024 Jun.
Bone repair via endochondral ossification is a complex process for the critical size reparation of bone defects. Tissue engineering strategies are being developed as alternative treatments to autografts or allografts. Most approaches to bone regeneration involve the use of calcium composites. However, exploring calcium-free alternatives in endochondral bone repair has emerged as a promising way to contribute to bone healing. By analyzing researches from the last ten years, this review identifies the potential benefits of such alternatives compared to traditional calcium-based approaches. Understanding the impact of calcium-free alternatives on endochondral bone repair can have profound implications for orthopedic and regenerative medicine. This review evaluates the efficacy of calcium-free alternatives in endochondral bone repair through trials. The findings may guide future research to develop innovative strategies to improve endochondral bone repair without relying on calcium. Exploring alternative approaches may lead to the discovery of novel therapies that improve bone healing outcomes.
通过软骨内成骨进行骨修复是骨缺损临界尺寸修复的一个复杂过程。组织工程策略正在被开发作为自体移植或异体移植的替代治疗方法。大多数骨再生方法都涉及使用钙复合材料。然而，探索软骨内骨修复中无钙替代物已成为促进骨愈合的一种有前景的方式。通过分析过去十年的研究，本综述确定了此类替代物相对于传统钙基方法的潜在益处。了解无钙替代物对软骨内骨修复的影响可能对骨科和再生医学产生深远影响。本综述通过试验评估了无钙替代物在软骨内骨修复中的疗效。这些发现可能会指导未来的研究，以开发创新策略来改善软骨内骨修复而不依赖钙。探索替代方法可能会导致发现改善骨愈合结果的新疗法。
