Carlsson L, Röstlund T, Albrektsson B, Albrektsson T, Brånemark P I
Acta Orthop Scand. 1986 Aug;57(4):285-9. doi: 10.3109/17453678608994393.
Forty-eight screws, six double cylindrical implants and six T-plates were inserted into the tibia or femur of 6 dogs. Two titanium screws were inserted into the proximal tibia of 5 patients to anchor a titanium mould. The implants were removed en bloc with adjacent bone tissue after 3 to 14 months. They were sectioned using a technique that allowed analysis of the intact tissue-to-metal specimens. Osseointegration, defined as a direct bone-to-implant contact without interposed soft tissue, was confirmed in all screw-shaped implants while the cylindres had only partial bone contact as did the T-plates. We conclude that osseointegrated implants may be applicable in joint reconstruction for arthrosis or rheumatoid arthritis.
将48枚螺钉、6个双圆柱形植入物和6块T形钢板植入6只狗的胫骨或股骨。将2枚钛螺钉插入5名患者的胫骨近端以固定一个钛模具。3至14个月后，将植入物与相邻骨组织整块取出。采用一种能对完整的组织-金属标本进行分析的技术对其进行切片。骨整合定义为骨与植入物直接接触且无软组织介入，在所有螺钉形植入物中均得到证实，而圆柱形植入物和T形钢板仅有部分骨接触。我们得出结论，骨整合植入物可能适用于关节病或类风湿性关节炎的关节重建。
