Singapore Institute of Manufacturing Technology (SIMTech), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis #08-04, Singapore 138634, Singapore.
Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore 117583, Singapore.
Biosensors (Basel). 2023 Sep 28;13(10):912. doi: 10.3390/bios13100912.
Auxotrophic primates like human beings rely on exogenous dietary vitamin B supplementation to meet their metabolic demands. Folates play a crucial role in nucleotide synthesis and DNA methylation. Maternal folate deficiency causes several pregnancy-related complications, perinatal defects, and early childhood cognitive impairments. New evidence suggests excess FA is a potential risk factor resulting in unfavourable genomic and epigenomic alterations. Thus, it is essential to revisit the need to consistently monitor maternal folate levels during pregnancy. Yet, to date, no point-of-care folate-monitoring biosensor is commercially available. Here, we critically appraise the advances in folate biosensors to understand the translational gaps in biosensor design. Further, our review sheds light on the potential role of folate biosensors in strengthening maternal, perinatal, and child healthcare.
营养缺陷型灵长类动物（如人类）依赖于外源性膳食维生素 B 补充来满足其代谢需求。叶酸在核苷酸合成和 DNA 甲基化中起着关键作用。母体叶酸缺乏会导致多种妊娠相关并发症、围产期缺陷和儿童早期认知障碍。新证据表明，过量的 FA 是导致基因组和表观基因组改变的潜在危险因素。因此，有必要重新审视在妊娠期间持续监测母体叶酸水平的必要性。然而，迄今为止，还没有商品化的即时检测叶酸监测生物传感器。在这里，我们批判性地评估了叶酸生物传感器的进展，以了解生物传感器设计中的转化差距。此外，我们的综述还揭示了叶酸生物传感器在加强母婴和儿童保健方面的潜在作用。
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