Franco Carolina N, Seabrook Laurence J, Nguyen Steven T, Leonard Jack T, Albrecht Lauren V
Department of Pharmaceutical Sciences, University of California, Irvine, CA 92697, USA.
Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA.
Metabolites. 2022 Oct 11;12(10):961. doi: 10.3390/metabo12100961.
Vitamin B micronutrients are essential regulators of one carbon metabolism that ensures human health. Vitamin B9, or folate, lies at the heart of the folate cycle and converges with the methionine cycle to complete the one carbon pathway. Additionally, vitamin B6 contributes by orchestrating the flux of one carbon cycling. Dysregulation of vitamin B contributes to altered biochemical signaling that manifests in a spectrum of human diseases. This review presents an analysis of the past, present, and future work, highlighting the interplay between folate and vitamin B6 in one carbon metabolism. Emerging insights include advances in metabolomic-based mass spectrometry and the use of live-cell metabolic labeling. Cancer is used as a focal point to dissect vitamin crosstalk and highlight new insights into the roles of folate and vitamin B6 in metabolic control. This collection of vitamin-based research detailing the trends of one carbon metabolism in human disease exemplifies how the future of personalized medicine could unfold using this new base of knowledge and ultimately provide next-generation therapeutics.
维生素B类微量营养素是确保人类健康的一碳代谢的重要调节因子。维生素B9，即叶酸，处于叶酸循环的核心位置，并与甲硫氨酸循环交汇以完成一碳途径。此外，维生素B6通过协调一碳循环的通量发挥作用。维生素B的失调会导致生化信号改变，进而表现为一系列人类疾病。本综述对过去、现在和未来的研究工作进行了分析，强调了叶酸和维生素B6在一碳代谢中的相互作用。新出现的见解包括基于代谢组学的质谱分析进展以及活细胞代谢标记的应用。癌症被用作剖析维生素相互作用的焦点，并突出叶酸和维生素B6在代谢控制中的作用的新见解。这一系列基于维生素的研究详细阐述了人类疾病中一碳代谢的趋势，例证了利用这一新知识基础个性化医疗的未来可能如何展开，并最终提供下一代治疗方法。
