Martini Caroline Lopes, Silva Deborah Nascimento Santos, Viana Alice Slotfeldt, Planet Paul Joseph, Figueiredo Agnes Marie Sá, Ferreira-Carvalho Bernadete Teixeira
Departamento de Microbiologia Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Antibiotics (Basel). 2023 Oct 11;12(10):1530. doi: 10.3390/antibiotics12101530.
is known to be associated with a variety of infections, from pharyngitis to necrotizing fasciitis (flesh-eating disease). of the ST62/87 lineage is recognized as one of the most frequently isolated lineages of invasive infections caused by this bacterium, which may be involved in hospital outbreaks and cluster infections. Despite this, comparative genomic and phylogenomic studies have not yet been carried out for this lineage. Thus, its virulence and antimicrobial susceptibility profiles are mostly unknown, as are the genetic relationships and evolutionary traits involving this lineage. Previously, a strain of ST62/87 (37-97) was characterized in our lab for its ability to generate antibiotic-persistent cells, and therapeutic failure in severe invasive infections caused by this bacterial species is well-reported in the scientific literature. In this work, we analyzed genomic and phylogenomic characteristics and evaluated the virulence and resistance profiles of ST62/87 from Brazil and international sources. Here we show that strains that form this lineage (ST62/87) are internationally spread, involved in invasive outbreaks, and share important virulence profiles with the most common types of , such as 1, 3, 12, and 69, which are associated with most invasive infections caused by this bacterial species in the USA and Europe. Accordingly, the continued increase of ST62/87 in severe diseases should not be underestimated.
已知它与多种感染有关，从咽炎到坏死性筋膜炎（噬肉病）。ST62/87谱系被认为是由这种细菌引起的侵袭性感染中最常分离出的谱系之一，可能与医院爆发和聚集性感染有关。尽管如此，尚未对该谱系进行比较基因组学和系统发育基因组学研究。因此，其毒力和抗菌药敏谱大多未知，涉及该谱系的遗传关系和进化特征也同样未知。此前，我们实验室对一株ST62/87（37-97）产生抗生素持续性细胞的能力进行了表征，并且科学文献中也有关于该细菌物种引起的严重侵袭性感染治疗失败的报道。在这项工作中，我们分析了来自巴西和国际来源的ST62/87的基因组和系统发育基因组特征，并评估了其毒力和耐药谱。在这里我们表明，形成该谱系（ST62/87）的菌株在国际上广泛传播，参与侵袭性疫情爆发，并与最常见的[细菌名称]类型（如1、3、12和69型）共享重要的毒力谱，这些类型与美国和欧洲由该细菌物种引起的大多数侵袭性感染有关。因此，不应低估ST62/87在严重[疾病名称]中持续增加的情况。
