Voudouris Dimitrios, Horianopoulou Maria, Apostolopoulou Zoi, Chryssanthopoulos Costas, Bardopoulou Mari, Maridaki Maria, Vassilakopoulos Theodoros, Koutsilieris Michael, Philippou Anastassios
Department of Physiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Department of Physical Education and Sport Science, School of Physical Education and Sport Science, National and Kapodistrian University of Athens, 17237 Athens, Greece.
Metabolites. 2023 Oct 13;13(10):1074. doi: 10.3390/metabo13101074.
Non-alcoholic fatty liver disease (NAFLD) is a very common liver disease associated with obesity, unhealthy diet, and lack of physical exercise. Short-term aerobic or resistance exercise has been shown to result in reduced liver fat in patients with NAFLD; however, the impact of the combination of these types of exercise has received less attention. This study investigated the effect of a short-term (7 days) concurrent exercise training program performed daily on liver steatosis indices, as well as the glycemic and lipidemic profile of overweight/obese sedentary volunteers. Twenty adult patients (age: 47.3 ± 12.3 yrs, body mass index: 32.4 ± 3.4 kg/m) with NAFLD, detected by ultrasound and hematological indices, participated in the study. Pre- and post-exercise intervention assessment included body weight (BW), waist circumference (WC), hip/waist ratio (H/W), Homeostasis Model Assessment Insulin Resistance (HOMA-IR), blood lipids, and steatosis indices. Fatty Liver Index, Lipid Accumulation Index, WC, H/W, triglycerides, and total cholesterol were improved ( < 0.05) post-exercise, while no differences ( > 0.05) were observed in BW, HOMA-IR, HDL, LDL, Hepatic Steatosis Index, and Framingham Steatosis Index compared to pre-exercise values. It is concluded that a 7-day combined exercise program can have beneficial effects on hepatic steatosis and central adiposity indices, independently of weight loss, in patients with NAFLD.
非酒精性脂肪性肝病（NAFLD）是一种与肥胖、不健康饮食和缺乏体育锻炼相关的非常常见的肝脏疾病。短期有氧运动或抗阻运动已被证明可使NAFLD患者的肝脏脂肪减少；然而，这些运动类型组合的影响较少受到关注。本研究调查了每天进行的短期（7天）联合运动训练计划对肝脏脂肪变性指标以及超重/肥胖久坐志愿者的血糖和血脂状况的影响。通过超声和血液学指标检测出20名患有NAFLD的成年患者（年龄：47.3±12.3岁，体重指数：32.4±3.4kg/m²）参与了该研究。运动干预前后的评估包括体重（BW）、腰围（WC）、臀围/腰围比（H/W）、稳态模型评估胰岛素抵抗（HOMA-IR）、血脂和脂肪变性指标。运动后脂肪肝指数、脂质蓄积指数、WC、H/W、甘油三酯和总胆固醇得到改善（P<0.05），而与运动前相比，BW、HOMA-IR、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、肝脏脂肪变性指数和弗明汉姆脂肪变性指数无差异（P>0.05）。结论是，7天的联合运动计划对NAFLD患者的肝脏脂肪变性和中心性肥胖指标可产生有益影响，且与体重减轻无关。
