Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education & Key Laboratory Pharmaceutical Engineering of Zhejiang Province & College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.
Mar Drugs. 2023 Oct 22;21(10):547. doi: 10.3390/md21100547.
In the post-antibiotic era, the rapid development of antibiotic resistance and the shortage of available antibiotics are triggering a new health-care crisis. The discovery of novel and potent antibiotics to extend the antibiotic pipeline is urgent. Small-molecule antimicrobial peptides have a wide variety of antimicrobial spectra and multiple innovative antimicrobial mechanisms due to their rich structural diversity. Consequently, they have become a new research hotspot and are considered to be promising candidates for next-generation antibiotics. Therefore, we have compiled a collection of small-molecule antimicrobial peptides derived from marine microorganisms from the last fifteen years to show the recent advances in this field. We categorize these compounds into three classes-cyclic oligopeptides, cyclic depsipeptides, and cyclic lipopeptides-according to their structural features, and present their sources, structures, and antimicrobial spectrums, with a discussion of the structure activity relationships and mechanisms of action of some compounds.
在抗生素时代后，抗生素耐药性的迅速发展和可用抗生素的短缺引发了新的医疗保健危机。发现新型强效抗生素以延长抗生素库是当务之急。由于其丰富的结构多样性，小分子抗菌肽具有广泛的抗菌谱和多种创新的抗菌机制。因此，它们已成为新的研究热点，并被认为是下一代抗生素的有前途的候选物。因此，我们汇集了过去十五年中来自海洋微生物的小分子抗菌肽，以展示该领域的最新进展。我们根据结构特征将这些化合物分为三类-环寡肽，环去肽和环脂肽-并介绍它们的来源，结构和抗菌谱，并讨论一些化合物的结构-活性关系和作用机制。
