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特定分子如何导致暴饮暴食。

How specific molecules can lead to overeating.

机构信息

Instituto de Investigaciones Bioquímicas de Bahía Blanca (INIBIBB), UNS-CONICET, Bahía Blanca, Argentina.

Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional Del Sur, Bahía Blanca, Argentina.

出版信息

Elife. 2023 Oct 27;12:e93090. doi: 10.7554/eLife.93090.

DOI:10.7554/eLife.93090
PMID:37889153
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10611429/
Abstract

A molecular pathway involving compounds found in processed foods and biogenic amines increases food intake and aging in the roundworm .

摘要

一种涉及加工食品中发现的化合物和生物胺的分子途径会增加线虫的食物摄入和衰老。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c98a/10611429/1ef1d6c6dff6/elife-93090-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c98a/10611429/1ef1d6c6dff6/elife-93090-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c98a/10611429/1ef1d6c6dff6/elife-93090-fig1.jpg

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How specific molecules can lead to overeating.特定分子如何导致暴饮暴食。
Elife. 2023 Oct 27;12:e93090. doi: 10.7554/eLife.93090.
2
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本文引用的文献

1
Methylglyoxal-derived hydroimidazolone, MG-H1, increases food intake by altering tyramine signaling via the GATA transcription factor ELT-3 in .甲基乙二醛衍生的羟咪唑啉酮,MG-H1,通过 GATA 转录因子 ELT-3 改变酪胺信号来增加食物摄入。
Elife. 2023 Sep 20;12:e82446. doi: 10.7554/eLife.82446.
2
Advanced Glycation End Products in Health and Disease.健康与疾病中的晚期糖基化终末产物
Microorganisms. 2022 Sep 15;10(9):1848. doi: 10.3390/microorganisms10091848.
3
The flight response impairs cytoprotective mechanisms by activating the insulin pathway.
飞行反应通过激活胰岛素途径来损害细胞保护机制。
Nature. 2019 Sep;573(7772):135-138. doi: 10.1038/s41586-019-1524-5. Epub 2019 Aug 28.
4
Adrenal Aging and Its Implications on Stress Responsiveness in Humans.肾上腺衰老及其对人类应激反应的影响。
Front Endocrinol (Lausanne). 2019 Feb 7;10:54. doi: 10.3389/fendo.2019.00054. eCollection 2019.
5
A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification.秀丽隐杆线虫模型揭示了TRPA1-Nrf信号通路在活性α-二羰基解毒中的保守作用。
Curr Biol. 2016 Nov 21;26(22):3014-3025. doi: 10.1016/j.cub.2016.09.024. Epub 2016 Oct 20.
6
Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding.对秀丽隐杆线虫中调节脂肪和进食的感觉回路进行神经和分子剖析。
Cell Metab. 2008 Aug;8(2):118-31. doi: 10.1016/j.cmet.2008.06.005.
7
Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation.晚期糖基化终末产物与受体(RAGE):衰老、糖尿病、神经退行性变及炎症中的共同线索
Glycobiology. 2005 Jul;15(7):16R-28R. doi: 10.1093/glycob/cwi053. Epub 2005 Mar 10.