Aksel S, Saracoglu O F, Yeoman R R, Wiebe R H
Am J Obstet Gynecol. 1986 Dec;155(6):1219-23. doi: 10.1016/0002-9378(86)90147-x.
Cytosolic estradiol and progesterone receptor concentrations were measured in luteal phase endometrial biopsy samples obtained from 12 anovulatory or oligoovulatory women on clomiphene citrate therapy and from 40 normal control subjects. Clomiphene citrate treatment (250 to 750 mg per cycle) decreased both endometrial estradiol and progesterone receptor concentrations. Estradiol receptor levels were nondetectable in seven tissue samples and progesterone receptor levels in four samples from the 12 subjects given clomiphene citrate compared to nondetectable estradiol receptor concentrations in one tissue sample and progesterone receptor concentrations in two samples from the 40 normal control subjects. In histologically dated endometrium, mean estradiol receptor concentrations on days 20 to 23 and progesterone receptor levels on days to 24 to 27 were lower than the values observed in the comparable dated endometrium of normal ovulatory women. Steroid receptor concentrations correlated negatively with the duration of clomiphene citrate therapy, which implies a time-dependent suppressive effect of clomiphene citrate on measurable cytosolic estradiol and progesterone receptor concentrations during the luteal phase of the cycle.
对12名接受枸橼酸氯米芬治疗的无排卵或排卵稀少的女性以及40名正常对照者黄体期子宫内膜活检样本中的胞质雌二醇和孕酮受体浓度进行了测定。枸橼酸氯米芬治疗（每周期250至750毫克）降低了子宫内膜雌二醇和孕酮受体浓度。与40名正常对照者的一个组织样本中未检测到雌二醇受体浓度以及两个样本中未检测到孕酮受体浓度相比，在接受枸橼酸氯米芬治疗的12名受试者中，7个组织样本中未检测到雌二醇受体水平，4个样本中未检测到孕酮受体水平。在组织学确定日期的子宫内膜中，第20至23天的平均雌二醇受体浓度和第24至27天的孕酮受体水平低于正常排卵女性同期子宫内膜中的观察值。类固醇受体浓度与枸橼酸氯米芬治疗持续时间呈负相关，这意味着枸橼酸氯米芬在周期黄体期对可测量的胞质雌二醇和孕酮受体浓度具有时间依赖性抑制作用。
