McLaughlin M K, Keve T M
Am J Obstet Gynecol. 1986 Dec;155(6):1296-9. doi: 10.1016/0002-9378(86)90163-8.
This study was designed to examine the effect of reproductive status on the basic mechanical properties of resistance size blood vessels. The hypothesis to be tested was that pregnancy is associated with alterations in both the passive and active properties of blood vessels small enough to be major determinants of peripheral vasculature resistance. Third-order arteries (165 microns in diameter) from the mesenteric arcade of the rat were removed at all three stages of gestation and the four stages of the estrous cycle. These were placed in a specially designed myograph system in which their active and passive tension-internal circumference characteristics were measured. Pregnancy was found to be associated with a decrease in stiffness of these vessels and a reduction in contractile ability by 20 days' gestation.
本研究旨在探讨生殖状态对阻力型血管基本力学特性的影响。待检验的假设是，妊娠与小到足以成为外周血管阻力主要决定因素的血管的被动和主动特性改变有关。在妊娠的所有三个阶段以及动情周期的四个阶段，从大鼠肠系膜弓取下直径为165微米的三级动脉。将这些动脉置于专门设计的肌动描记系统中，测量其主动和被动张力-内径特性。研究发现，妊娠与这些血管的僵硬度降低以及妊娠20天时收缩能力下降有关。
