University of Turku, Turku, Finland.
Department of Orthopaedic Surgery, Turku University Hospital, Turku, Finland.
Transplant Proc. 2023 Dec;55(10):2345-2353. doi: 10.1016/j.transproceed.2023.09.030. Epub 2023 Oct 25.
The objective of a musculoskeletal tissue bank is to collect, test, store, and provide musculoskeletal tissue allografts required in orthopedic procedures. Strict exclusion criteria are followed when selecting suitable cadaver musculoskeletal tissue donors, and the allografts are procured under sterile conditions to avoid bacterial contamination. Tissue banking in Turku, Finland, began in 1972, and tissue bank services were last reviewed in 2003. This study aimed to review the operation of the musculoskeletal tissue bank in Turku, Finland, between 2014 and 2020 and to analyze the number, types, and contamination rate of the allografts procured from the cadaver donors. Potential donor-related factors causing bacterial contamination of the allografts and whether potential musculoskeletal tissue donors were overlooked among multiorgan donors were also studied.
A retrospective review of all cadaver musculoskeletal tissue donors used in the Hospital District of Southwest Finland Tyks Orto Musculoskeletal Tissue Bank during the study period was conducted, and data on the procured allograft was collected and presented. The donors were selected among patients treated in the intensive care unit (ICU) of Turku University Hospital (TYKS).
A total of 28 cadaver donors were used, and 636 allografts were procured between 2014 and 2020. The bacterial contamination rate was 2.5%, which was lower than that in the previous international literature. The median treatment time in the ICU was significantly longer, and the median value of the highest C-reactive protein level was significantly higher in the group of donors with positive allograft bacterial cultures.
The bacterial contamination rate in the tissue bank was low on an international scale. Some suitable musculoskeletal tissue donors were overlooked among multiorgan donors.
肌骨组织库的目标是收集、测试、储存和提供骨科手术所需的肌骨组织同种异体移植物。在选择合适的尸体肌骨组织供体时，遵循严格的排除标准，并且在无菌条件下获取同种异体移植物以避免细菌污染。芬兰图尔库的组织库始于 1972 年，2003 年对组织库服务进行了最后审查。本研究旨在回顾 2014 年至 2020 年期间芬兰图尔库肌骨组织库的运作情况，并分析从尸体供体获取的同种异体移植物的数量、类型和污染率。还研究了导致同种异体移植物细菌污染的潜在供体相关因素，以及多器官供体中是否忽略了潜在的肌骨组织供体。
对研究期间芬兰西南地区图尔库医院区使用的所有尸体肌骨组织供体进行了回顾性审查，并收集和呈现了获取的同种异体移植物的数据。供体选自图尔库大学医院（TYKS）重症监护病房（ICU）治疗的患者。
共有 28 名尸体供体被使用，2014 年至 2020 年间共获取了 636 个同种异体移植物。细菌污染率为 2.5%，低于国际文献中的先前水平。在 ICU 中的治疗时间中位数明显更长，且同种异体移植物细菌培养阳性供体的 C 反应蛋白水平的最高值中位数明显更高。
组织库中的细菌污染率在国际范围内较低。多器官供体中忽略了一些合适的肌骨组织供体。
