Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Division of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan.
Eur J Clin Nutr. 2024 Jan;78(1):34-42. doi: 10.1038/s41430-023-01349-w. Epub 2023 Oct 27.
In recent years, an increasing number of epidemiological studies have suggested a role of polyphenols in the prevention of chronic diseases. Prospective cohort studies have typically measured polyphenol concentrations in a single blood sample and the reproducibility of plasma polyphenol measurements is largely unknown.
We evaluated the reproducibility of 35 plasma polyphenols collected at an interval of 1-year. We also examined correlations of these polyphenols with food group intakes calculated from weighed food records (WFR) and food frequency questionnaire (FFQ).
The study included 227 middle-aged participants from the JPHC-NEXT Protocol Area in Japan. We measured 35 polyphenols in plasma collected at two points 1-year apart. Food group intakes were calculated from 12-day WFR and FFQ. For the reproducibility analysis, the intraclass correlation coefficient (ICC) of 35 polyphenol concentrations were examined between the two points. Pearson's partial correlations was used to assess the correlation between polyphenols and food groups.
Moderate- to high ICCs were observed for tea-originated polyphenols such as gallic acid, quercetin, epigallocatechin, and kaempferol - and coffee-derived polyphenols, such as caffeic acid, and ferulic acid. For the dietary analyses, moderate correlations were observed for non-alcoholic beverages intake and epigallocatechin, epicatechin, catechin, and gallic acid. For green tea, higher correlations were observed with these polyphenols.
Plasma concentrations of tea and coffee-related polyphenols, except for catechin, had good reproducibility over a 1-year period. The correlations between intake of non-alcoholic beverages, particularly green tea, and tea polyphenols, indicated moderate- to high correlations.
近年来，越来越多的流行病学研究表明，多酚在预防慢性病方面发挥着作用。前瞻性队列研究通常在单个血液样本中测量多酚浓度，而血浆多酚测量的可重复性在很大程度上是未知的。
我们评估了在 1 年间隔时间内采集的 35 种血浆多酚的重现性。我们还检查了这些多酚与从称重食物记录（WFR）和食物频率问卷（FFQ）计算得出的食物组摄入量之间的相关性。
本研究包括来自日本 JPHC-NEXT 协议区的 227 名中年参与者。我们测量了相隔 1 年采集的 2 个时间点的 35 种血浆多酚。食物组摄入量是从 12 天的 WFR 和 FFQ 计算得出的。为了进行重现性分析，检查了两个时间点之间 35 种多酚浓度的组内相关系数（ICC）。使用 Pearson 部分相关来评估多酚与食物组之间的相关性。
观察到茶源多酚，如没食子酸、槲皮素、表儿茶素和山奈酚 - 和咖啡源多酚，如咖啡酸和阿魏酸的 ICC 处于中等到高水平。对于饮食分析，观察到非酒精性饮料摄入与表儿茶素、表儿茶素、儿茶素和没食子酸之间存在中度相关性。对于绿茶，与这些多酚的相关性更高。
在 1 年期间，除儿茶素外，茶和咖啡相关多酚的血浆浓度具有良好的重现性。非酒精性饮料，特别是绿茶，与茶多酚之间的摄入量相关性表明，相关性处于中等至高水平。
